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The Difference in Prognostic Factors between Early Recurrence and Late Recurrence in Estrogen Receptor-Positive Breast Cancer: Nodal Stage Differently Impacts Early and Late Recurrence

Authors
 Sung Gwe Ahn  ;  Hak Min Lee  ;  Sang-Hoon Cho  ;  Suk Jin Bae  ;  Seung Ah Lee  ;  Seung Hyun Hwang  ;  Joon Jeong  ;  Hy-De Lee 
Citation
 PLOS ONE, Vol.8(5) : e63510, 2013 
Journal Title
 PLOS ONE 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology* ; Combined Modality Therapy/methods ; Female ; Humans ; Lymph Nodes/pathology* ; Lymphatic Metastasis/genetics ; Lymphatic Metastasis/pathology* ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology* ; Prognosis ; Receptors, Estrogen/genetics* ; Retrospective Studies ; Young Adult
Keywords
Adult ; Aged ; Aged, 80 and over ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Breast Neoplasms/pathology* ; Combined Modality Therapy/methods ; Female ; Humans ; Lymph Nodes/pathology* ; Lymphatic Metastasis/genetics ; Lymphatic Metastasis/pathology* ; Middle Aged ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/genetics ; Neoplasm Recurrence, Local/pathology* ; Prognosis ; Receptors, Estrogen/genetics* ; Retrospective Studies ; Young Adult
Abstract
BACKGROUND: Probability of recurrence in patients with estrogen receptor (ER)-positive breast cancer remains constant for long periods. We compared tumor burden impact on late versus early recurrence in our cohort with long-term follow-up. METHODS: Five hundred and ninety five patients diagnosed with ER-positive breast cancer between 1989 and 2001 were classified into three groups: early recurrence within 5 years, late recurrence after 5 years, and no recurrence. We identified prognostic factors among the groups using logistic regression analysis. RESULTS: At median follow-up of 11.7 years, among 595 ER-positive women, 98 (16.4%) had early recurrence and 58 (9.7%) had late recurrence. On multivariate analysis, higher nodal stage (N0 vs. N2, odds ratio [OR] 3.189; N0 vs. N3, OR 9.948), higher histologic grade (grade 1 vs. grade 2, OR 3.896; grade 1 vs. grade 3, OR 5.945), age >35 years (OR 0.295), and receiving endocrine therapy (OR 0.293) affected early recurrence. Compared to no recurrence, receiving endocrine therapy (OR 0.285) was solely related to decreased risk of late recurrence. Increased risk of early recurrence was noted with the higher nodal stage when early and no recurrences were compared. This phenomenon was not found in late recurrence. In the last comparison between the early and late recurrence, higher nodal stage (N0 vs. N3, OR 16.779) and higher histologic grade (grade 1 vs. grade 3, OR 18.111) repeatedly weighted for early recurrence. CONCLUSIONS: Nodal burden had an attenuated influence on late recurrence, which suggests that, unlike early recurrence, tumor biology might have a more important role than tumor load for late recurrence in ER-positive disease.
Files in This Item:
T201301731.pdf Download
DOI
10.1371/journal.pone.0063510
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Lee, Seung Ah(이승아)
Lee, Hak Min(이학민)
Lee, Hy De(이희대)
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Hwang, Seung Hyun(황승현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/87027
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