128 249

Cited 0 times in

Survival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1

DC FieldValueLanguage
dc.contributor.author박준희-
dc.contributor.author이창연-
dc.contributor.author황기철-
dc.date.accessioned2014-12-18T08:45:57Z-
dc.date.available2014-12-18T08:45:57Z-
dc.date.issued2013-
dc.identifier.issn1229-845X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86911-
dc.description.abstractThe use of mesenchymal stem cells (MSCs) has emerged as a potential new treatment for myocardial infarction. However, the poor viability of MSCs after transplantation critically limits the efficacy of this new strategy. The expression of microRNA-210 (miR-210) is induced by hypoxia and is important for cell survival under hypoxic conditions. Hypoxia increases the levels of hypoxia inducible factor-1 (HIF-1) protein and miR-210 in human MSCs (hMSCs). miR-210 positively regulates HIF-1α activity. Furthermore, miR-210 expression is also induced by hypoxia through the regulation of HIF-1α. To investigate the effect of miR-210 on hMSC survival under hypoxic conditions, survival rates along with signaling related to cell survival were evaluated in hMSCs over-expressing miR-210 or ones that lacked HIF-1α expression. Elevated miR-210 expression increased survival rates along with Akt and ERK activity in hMSCs with hypoxia. These data demonstrated that a positive feedback loop involving miR-210 and HIF-1α was important for MSC survival under hypoxic conditions.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfJOURNAL OF VETERINARY SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHCell Survival-
dc.subject.MESHCobalt-
dc.subject.MESHGene Expression Regulation/physiology*-
dc.subject.MESHHumans-
dc.subject.MESHHypoxia-Inducible Factor 1, alpha Subunit/genetics-
dc.subject.MESHHypoxia-Inducible Factor 1, alpha Subunit/metabolism*-
dc.subject.MESHMesenchymal Stromal Cells/drug effects-
dc.subject.MESHMesenchymal Stromal Cells/metabolism-
dc.subject.MESHMesenchymal Stromal Cells/physiology*-
dc.subject.MESHMicroRNAs/metabolism*-
dc.subject.MESHOxygen/pharmacology-
dc.subject.MESHOxygen Consumption*-
dc.subject.MESHRNA, Small Interfering/metabolism-
dc.titleSurvival of hypoxic human mesenchymal stem cells is enhanced by a positive feedback loop involving miR-210 and hypoxia-inducible factor 1-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Life Science (의생명과학부)-
dc.contributor.googleauthorWoochul Chang-
dc.contributor.googleauthorChang Youn Lee-
dc.contributor.googleauthorJun-Hee Park-
dc.contributor.googleauthorMoon-Seo Park-
dc.contributor.googleauthorLee-So Maeng-
dc.contributor.googleauthorChee Soon Yoon-
dc.contributor.googleauthorMin Young Lee-
dc.contributor.googleauthorKi-Chul Hwang-
dc.contributor.googleauthorYong-An Chung-
dc.identifier.doi23388440-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA01679-
dc.contributor.localIdA03244-
dc.contributor.localIdA04456-
dc.relation.journalcodeJ01927-
dc.identifier.eissn1976-555X-
dc.identifier.pmid23388440-
dc.subject.keywordcell survival-
dc.subject.keywordhuman mesenchymal stem cells-
dc.subject.keywordhypoxia-
dc.subject.keywordhypoxia inducible factor-1-
dc.subject.keywordmicroRNA-210-
dc.contributor.alternativeNamePark, Jun-Hee-
dc.contributor.alternativeNameLee, Chang Yeon-
dc.contributor.alternativeNameHwang, Ki Chul-
dc.contributor.affiliatedAuthorPark, Jun-Hee-
dc.contributor.affiliatedAuthorLee, Chang Yeon-
dc.contributor.affiliatedAuthorHwang, Ki Chul-
dc.rights.accessRightsfree-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage69-
dc.citation.endPage76-
dc.identifier.bibliographicCitationJOURNAL OF VETERINARY SCIENCE, Vol.14(1) : 69-76, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.