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Clinical Analysis of Primary Eosinophilic Esophagitis

Authors
 Jung Ho Lee ; Moo Jung Kim ; Hyojin Park ; Yunju Jo ; Young-Tae Bak ; Nayoung Kim ; Young Hoon Youn ; Jie-Hyun Kim 
Citation
 Journal of Neurogastroenterology and Motility, Vol.19(2) : 204~209, 2013 
Journal Title
 Journal of Neurogastroenterology and Motility 
ISSN
 2093-0879 
Issue Date
2013
Abstract
Background/Aims Eosinophilic esophagitis (EoE) is a chronic inflammatory disorder of the esophagus. Similar to asthma, EoE can induce irreversible structural changes in the esophagus as a result of chronic and persistent eosinophilic inflammation. The aim of this study was to analyse changes in symptoms, eosinophil counts and endoscopic findings after treatment. Methods Nine patients with EoE (6 men and 3 women; mean age, 36.44 years) were diagnosed with EoE based on typical symptoms, endoscopic abnormalities and infiltration of the esophageal epithelium with ≥ 15 eosinophils/high-power field. The average endoscopic follow-up period was 10 months, ranging from 1 to 25 months. Symptoms and endoscopic and pathological findings at initial observation and follow-up were evaluated. Results Seven of the 9 patients had dysphagia symptoms, which improved in 4 of 6 patients who were treated with proton pump inhibitor. Two patients were unresponsive to proton pump inhibitor and another 2 patients were treated with corticosteroid, which led to symptomatic relief. In 8 patients, esophageal eosinophilia was improved histologically at follow-up after treatment. Six of the 9 patients had typical endoscopic findings of EoE at initial examination. Despite treatment, these findings remained in 5 of the 6 patients at follow-up endoscopy. Conclusions After treatment, the symptoms and eosinophil counts were temporarily improved, but the endoscopic findings of EoE were generally not improved. This indicates that deformity of esophageal structure due to eosinophilic inflammation might be irreversible despite proper management. Keywords: Endoscopy, Eosinophilic esophagitis, Inflammation
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86866
DOI
10.5056/jnm.2013.19.2.204
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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