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Lack of Either Estrogen or Progesterone Receptor Expression Is Associated with Poor Survival Outcome among Luminal A Breast Cancer Subtype

 Seho Park  ;  Byeong-Woo Park  ;  Tae Hyun Kim  ;  Chang Wan Jeon  ;  Han-Sung Kang  ;  Jung-Eun Choi  ;  Ki-Tae Hwang  ;  In Cheol Kim 
 ANNALS OF SURGICAL ONCOLOGY, Vol.20(5) : 1505-1513, 2013 
Journal Title
Issue Date
Adult ; Age Factors ; Breast Neoplasms/metabolism* ; Breast Neoplasms/pathology* ; Breast Neoplasms/therapy ; Chemotherapy, Adjuvant ; Disease-Free Survival ; Female ; Humans ; Kaplan-Meier Estimate ; Ki-67 Antigen/metabolism ; Middle Aged ; Neoplasm Grading ; Neoplasm Metastasis ; Proportional Hazards Models ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism* ; Receptors, Progesterone/metabolism* ; Registries ; Republic of Korea
Overall Survival ; Estrogen Receptor ; Luminal ; Progesterone Receptor ; Progesterone Receptor Expression
Background This study was designed to evaluate the impact of lack of either estrogen receptor (ER) or progesterone receptor (PR) on characteristics and outcomes among luminal A breast cancer subtype treated with endocrine with or without chemotherapeutic agents. Methods The luminal A subtype was categorized into three subgroups: ER+/PR+, ER+/PR−, and ER−/PR+. All tumors were human epidermal growth factor receptor 2 (HER2) negative. Clinicopathological features and survival were analyzed using the Severance Hospital dataset (n = 1,180) and were validated by the nationwide Korean Breast Cancer Society (KBCS) registry (n = 9,916). Results Despite the different distribution of ER/PR status, tumor stage, grade, and local therapies between the two datasets, similarly ER+/PR+ showed smaller size and good differentiation, ER+/PR− patients had the oldest age at diagnosis, and ER−/PR+ was associated with the youngest age at onset and grade III tumor. Single hormone receptor-positive subgroups demonstrated worse disease-related outcomes than the ER+/PR+ subgroup. These associations were confirmed by the KBCS dataset. This trend was also demonstrated in the subpopulation of 1,944 patients with Ki-67 < 14 %. Inferior survival of single receptor-positive tumors was more definite among node-positive patients even when receiving both chemo-endocrine therapies. Conclusions Current results suggest that the luminal A subtype is also heterogeneous and each subgroup has unique clinicopathologic characteristics. Lack of either ER or PR expression is associated with worse survival, especially among node-positive luminal A subtype.
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1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Park, Byeong Woo(박병우) ORCID logo https://orcid.org/0000-0003-1353-2607
Park, Se Ho(박세호) ORCID logo https://orcid.org/0000-0001-8089-2755
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