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Coagulopathy Caused by Concurrent Ciprofloxacin and Warfarin Use: What Other Factors Induce Coagulopathy?

 Sungmo Jung  ;  Misung Park  ;  Won Jin Kim  ;  Chang Oh Kim 
 Journal of the Korean Geriatrics Society (노인병), Vol.17(1) : 47-54, 2013 
Journal Title
 Journal of the Korean Geriatrics Society (노인병) 
Issue Date
Warfarin ; International normalized ratio ; Ciprofloxacin ; Coagulopation disorders ; Activities of daily living
Background To assess factors affecting the prolongation of the international normalized ratio (INR) with concurrent warfarin and ciprofloxacin use. Methods A retrospective case-control study was performed at a single, 2,000-bed tertiary hospital between January 2007 and December 2009. Thirty-three patients who were on warfarin and ciprofloxacin concurrently were enrolled. Demographics and clinical data were collected from medical records. Results Nine patients were assigned to the case group (prolonged INR) and 19 patients to the control group (normal INR). Activities of daily living (ADL) and total number of classes of medications taken demonstrated significant differences between the groups (15.33 vs. 7.11, p<0.001; 7.11 vs. 5.47, p=0.041). No bleeding complications occurred during this study. Conclusion As ADL reflects patient performance status and general condition of an individual, we conclude that a poor general condition is associated with coagulopathy in persons concurrently using warfarin and ciprofloxacin.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Jin(김원진)
Kim, Chang Oh(김창오) ORCID logo https://orcid.org/0000-0002-0773-5443
Park, Mi Sung(박미성)
Jung, Sung Mo(정성모)
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