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Circulating α-klotho levels in CKD and relationship to progression

DC FieldValueLanguage
dc.contributor.author구향모-
dc.contributor.author김동욱-
dc.contributor.author김찬호-
dc.contributor.author김형래-
dc.contributor.author남보영-
dc.contributor.author도화미-
dc.contributor.author오형중-
dc.contributor.author유태현-
dc.contributor.author이미정-
dc.contributor.author한대석-
dc.contributor.author한승혁-
dc.contributor.author한재현-
dc.contributor.author강민웅-
dc.contributor.author강신욱-
dc.contributor.author고광일-
dc.date.accessioned2014-12-18T08:43:04Z-
dc.date.available2014-12-18T08:43:04Z-
dc.date.issued2013-
dc.identifier.issn0272-6386-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86823-
dc.description.abstractBACKGROUND: α-Klotho is reported to have protective effects against kidney injury, and its renal expression is decreased in many experimental models of kidney disease. However, circulating α-klotho levels in human chronic kidney disease (CKD) and the relationship to progression are unknown. STUDY DESIGN: Post hoc analysis of a prospective cohort study. SETTING & PARTICIPANTS: 243 of 301 participants from a CKD cohort at our institution between January 2006 and December 2011 were eligible for the study. PREDICTOR: Baseline α-klotho levels. OUTCOMES: Primary outcome was the composite of doubling of baseline serum creatinine concentration, end-stage renal disease, or death. End-stage renal disease was defined as onset of treatment by renal replacement therapy. MEASUREMENTS: Serum α-klotho and fibroblast growth factor 23 (FGF-23) were measured using enzyme-linked immunosorbent assay. RESULTS: Lower serum α-klotho levels were associated with more severe CKD stage in the cross-sectional analysis of the baseline data (P for trend < 0.001). In the adjusted multivariable linear regression model, log(α-klotho) was associated independently with estimated glomerular filtration rate (β = 0.154; P = 0.001). Cox regression analysis showed that baseline α-klotho level independently predicted the composite outcome after adjustment for age, diabetes, blood pressure, estimated glomerular filtration rate, proteinuria, parathyroid hormone level, and FGF-23 level (HR per 10-pg/mL increase, 0.96; 95% CI, 0.94-0.98; P < 0.001). When patients were categorized into 2 groups according to baseline median α-klotho value, 43 (35.2%) patients with α-klotho levels ≤396.3 pg/mL reached the primary composite outcome compared with 19 (15.7%) with α-klotho levels >396.3 pg/mL (HR, 2.03; 95% CI, 1.07-3.85; P = 0.03). LIMITATIONS: Uncontrolled dietary phosphorus intake and use of frozen samples. CONCLUSIONS: This observational study showed that low circulating α-klotho levels were associated with adverse kidney disease outcome, suggesting that α-klotho is a novel biomarker for CKD progression. More data from larger prospective longitudinal studies are required to validate our findings-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfAmerican Journal of Kidney Diseases-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleCirculating α-klotho levels in CKD and relationship to progression-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.contributor.googleauthorHyoung Rae Kim-
dc.contributor.googleauthorBo Young Nam-
dc.contributor.googleauthorDong Wook Kim-
dc.contributor.googleauthorMin Woong Kang-
dc.contributor.googleauthorJae-Hyun Han-
dc.contributor.googleauthorMi Jung Lee-
dc.contributor.googleauthorDong Ho Shin-
dc.contributor.googleauthorFa Mee Doh-
dc.contributor.googleauthorHyang Mo Koo-
dc.contributor.googleauthorKwang Il Ko-
dc.contributor.googleauthorChan Ho Kim-
dc.contributor.googleauthorHyung Jung Oh-
dc.contributor.googleauthorTae-Hyun Yoo-
dc.contributor.googleauthorShin-Wook Kang-
dc.contributor.googleauthorDae Suk Han-
dc.contributor.googleauthorSeung Hyeok Han-
dc.identifier.doi10.1053/j.ajkd.2013.01.024-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00203-
dc.contributor.localIdA01037-
dc.contributor.localIdA01147-
dc.contributor.localIdA01251-
dc.contributor.localIdA01315-
dc.contributor.localIdA02097-
dc.contributor.localIdA02417-
dc.contributor.localIdA02526-
dc.contributor.localIdA04272-
dc.contributor.localIdA04304-
dc.contributor.localIdA04320-
dc.contributor.localIdA00027-
dc.contributor.localIdA00053-
dc.contributor.localIdA00110-
dc.contributor.localIdA02773-
dc.contributor.localIdA00407-
dc.relation.journalcodeJ00089-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0272638613004794-
dc.contributor.alternativeNameKoo, Hyang Mo-
dc.contributor.alternativeNameKim, Dong Wook-
dc.contributor.alternativeNameKim, Chan Ho-
dc.contributor.alternativeNameKim, Hyoung Rae-
dc.contributor.alternativeNameNam, Bo Young-
dc.contributor.alternativeNameDoh, Fa Mee-
dc.contributor.alternativeNameShin, Dong Ho-
dc.contributor.alternativeNameOh, Hyung Jung-
dc.contributor.alternativeNameYoo, Tae Hyun-
dc.contributor.alternativeNameLee, Mi Jung-
dc.contributor.alternativeNameHan, Dae Suk-
dc.contributor.alternativeNameHan, Seung Hyeok-
dc.contributor.alternativeNameHan, Jae Hyun-
dc.contributor.alternativeNameKang, Min Woong-
dc.contributor.alternativeNameKang, Shin Wook-
dc.contributor.alternativeNameKo, Kwang Il-
dc.contributor.affiliatedAuthorKoo, Hyang Mo-
dc.contributor.affiliatedAuthorKim, Chan Ho-
dc.contributor.affiliatedAuthorKim, Hyoung Rae-
dc.contributor.affiliatedAuthorNam, Bo Young-
dc.contributor.affiliatedAuthorDoh, Fa Mee-
dc.contributor.affiliatedAuthorShin, Dong Ho-
dc.contributor.affiliatedAuthorOh, Hyung Jung-
dc.contributor.affiliatedAuthorYoo, Tae Hyun-
dc.contributor.affiliatedAuthorHan, Dae Suk-
dc.contributor.affiliatedAuthorHan, Seung Hyeok-
dc.contributor.affiliatedAuthorHan, Jae Hyun-
dc.contributor.affiliatedAuthorKang, Min Woong-
dc.contributor.affiliatedAuthorKang, Shin Wook-
dc.contributor.affiliatedAuthorKo, Kwang Il-
dc.contributor.affiliatedAuthorLee, Mi Jung-
dc.contributor.affiliatedAuthorKim, Dong Wook-
dc.rights.accessRightsnot free-
dc.citation.volume61-
dc.citation.number6-
dc.citation.startPage899-
dc.citation.endPage909-
dc.identifier.bibliographicCitationAmerican Journal of Kidney Diseases, Vol.61(6) : 899-909, 2013-
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원)

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