Cited 148 times in
Circulating α-klotho levels in CKD and relationship to progression
DC Field | Value | Language |
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dc.contributor.author | 구향모 | - |
dc.contributor.author | 김동욱 | - |
dc.contributor.author | 김찬호 | - |
dc.contributor.author | 김형래 | - |
dc.contributor.author | 남보영 | - |
dc.contributor.author | 도화미 | - |
dc.contributor.author | 오형중 | - |
dc.contributor.author | 유태현 | - |
dc.contributor.author | 이미정 | - |
dc.contributor.author | 한대석 | - |
dc.contributor.author | 한승혁 | - |
dc.contributor.author | 한재현 | - |
dc.contributor.author | 강민웅 | - |
dc.contributor.author | 강신욱 | - |
dc.contributor.author | 고광일 | - |
dc.date.accessioned | 2014-12-18T08:43:04Z | - |
dc.date.available | 2014-12-18T08:43:04Z | - |
dc.date.issued | 2013 | - |
dc.identifier.issn | 0272-6386 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/86823 | - |
dc.description.abstract | BACKGROUND: α-Klotho is reported to have protective effects against kidney injury, and its renal expression is decreased in many experimental models of kidney disease. However, circulating α-klotho levels in human chronic kidney disease (CKD) and the relationship to progression are unknown. STUDY DESIGN: Post hoc analysis of a prospective cohort study. SETTING & PARTICIPANTS: 243 of 301 participants from a CKD cohort at our institution between January 2006 and December 2011 were eligible for the study. PREDICTOR: Baseline α-klotho levels. OUTCOMES: Primary outcome was the composite of doubling of baseline serum creatinine concentration, end-stage renal disease, or death. End-stage renal disease was defined as onset of treatment by renal replacement therapy. MEASUREMENTS: Serum α-klotho and fibroblast growth factor 23 (FGF-23) were measured using enzyme-linked immunosorbent assay. RESULTS: Lower serum α-klotho levels were associated with more severe CKD stage in the cross-sectional analysis of the baseline data (P for trend < 0.001). In the adjusted multivariable linear regression model, log(α-klotho) was associated independently with estimated glomerular filtration rate (β = 0.154; P = 0.001). Cox regression analysis showed that baseline α-klotho level independently predicted the composite outcome after adjustment for age, diabetes, blood pressure, estimated glomerular filtration rate, proteinuria, parathyroid hormone level, and FGF-23 level (HR per 10-pg/mL increase, 0.96; 95% CI, 0.94-0.98; P < 0.001). When patients were categorized into 2 groups according to baseline median α-klotho value, 43 (35.2%) patients with α-klotho levels ≤396.3 pg/mL reached the primary composite outcome compared with 19 (15.7%) with α-klotho levels >396.3 pg/mL (HR, 2.03; 95% CI, 1.07-3.85; P = 0.03). LIMITATIONS: Uncontrolled dietary phosphorus intake and use of frozen samples. CONCLUSIONS: This observational study showed that low circulating α-klotho levels were associated with adverse kidney disease outcome, suggesting that α-klotho is a novel biomarker for CKD progression. More data from larger prospective longitudinal studies are required to validate our findings | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | AMERICAN JOURNAL OF KIDNEY DISEASES | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Creatinine/blood | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Disease Progression | - |
dc.subject.MESH | Enzyme-Linked Immunosorbent Assay | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fibroblast Growth Factors/blood | - |
dc.subject.MESH | Glomerular Filtration Rate | - |
dc.subject.MESH | Glucuronidase/blood* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Failure, Chronic/blood | - |
dc.subject.MESH | Linear Models | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Prospective Studies | - |
dc.subject.MESH | Renal Insufficiency, Chronic/blood* | - |
dc.subject.MESH | Young Adult | - |
dc.title | Circulating α-klotho levels in CKD and relationship to progression | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Internal Medicine (내과학) | - |
dc.contributor.googleauthor | Hyoung Rae Kim | - |
dc.contributor.googleauthor | Bo Young Nam | - |
dc.contributor.googleauthor | Dong Wook Kim | - |
dc.contributor.googleauthor | Min Woong Kang | - |
dc.contributor.googleauthor | Jae-Hyun Han | - |
dc.contributor.googleauthor | Mi Jung Lee | - |
dc.contributor.googleauthor | Dong Ho Shin | - |
dc.contributor.googleauthor | Fa Mee Doh | - |
dc.contributor.googleauthor | Hyang Mo Koo | - |
dc.contributor.googleauthor | Kwang Il Ko | - |
dc.contributor.googleauthor | Chan Ho Kim | - |
dc.contributor.googleauthor | Hyung Jung Oh | - |
dc.contributor.googleauthor | Tae-Hyun Yoo | - |
dc.contributor.googleauthor | Shin-Wook Kang | - |
dc.contributor.googleauthor | Dae Suk Han | - |
dc.contributor.googleauthor | Seung Hyeok Han | - |
dc.identifier.doi | 10.1053/j.ajkd.2013.01.024 | - |
dc.admin.author | false | - |
dc.admin.mapping | false | - |
dc.contributor.localId | A00203 | - |
dc.contributor.localId | A01037 | - |
dc.contributor.localId | A01147 | - |
dc.contributor.localId | A01251 | - |
dc.contributor.localId | A01315 | - |
dc.contributor.localId | A02097 | - |
dc.contributor.localId | A02417 | - |
dc.contributor.localId | A02526 | - |
dc.contributor.localId | A04272 | - |
dc.contributor.localId | A04304 | - |
dc.contributor.localId | A04320 | - |
dc.contributor.localId | A00027 | - |
dc.contributor.localId | A00053 | - |
dc.contributor.localId | A00110 | - |
dc.contributor.localId | A02773 | - |
dc.contributor.localId | A00407 | - |
dc.relation.journalcode | J00089 | - |
dc.identifier.eissn | 1523-6838 | - |
dc.identifier.pmid | 23540260 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0272638613004794 | - |
dc.subject.keyword | α-Klotho | - |
dc.subject.keyword | fibroblast growth factor 23 (FGF-23) | - |
dc.subject.keyword | chronic kidney disease | - |
dc.subject.keyword | kidney disease outcome | - |
dc.contributor.alternativeName | Koo, Hyang Mo | - |
dc.contributor.alternativeName | Kim, Dong Wook | - |
dc.contributor.alternativeName | Kim, Chan Ho | - |
dc.contributor.alternativeName | Kim, Hyoung Rae | - |
dc.contributor.alternativeName | Nam, Bo Young | - |
dc.contributor.alternativeName | Doh, Fa Mee | - |
dc.contributor.alternativeName | Shin, Dong Ho | - |
dc.contributor.alternativeName | Oh, Hyung Jung | - |
dc.contributor.alternativeName | Yoo, Tae Hyun | - |
dc.contributor.alternativeName | Lee, Mi Jung | - |
dc.contributor.alternativeName | Han, Dae Suk | - |
dc.contributor.alternativeName | Han, Seung Hyeok | - |
dc.contributor.alternativeName | Han, Jae Hyun | - |
dc.contributor.alternativeName | Kang, Min Woong | - |
dc.contributor.alternativeName | Kang, Shin Wook | - |
dc.contributor.alternativeName | Ko, Kwang Il | - |
dc.contributor.affiliatedAuthor | Koo, Hyang Mo | - |
dc.contributor.affiliatedAuthor | Kim, Chan Ho | - |
dc.contributor.affiliatedAuthor | Kim, Hyoung Rae | - |
dc.contributor.affiliatedAuthor | Nam, Bo Young | - |
dc.contributor.affiliatedAuthor | Doh, Fa Mee | - |
dc.contributor.affiliatedAuthor | Shin, Dong Ho | - |
dc.contributor.affiliatedAuthor | Oh, Hyung Jung | - |
dc.contributor.affiliatedAuthor | Yoo, Tae Hyun | - |
dc.contributor.affiliatedAuthor | Han, Dae Suk | - |
dc.contributor.affiliatedAuthor | Han, Seung Hyeok | - |
dc.contributor.affiliatedAuthor | Han, Jae Hyun | - |
dc.contributor.affiliatedAuthor | Kang, Min Woong | - |
dc.contributor.affiliatedAuthor | Kang, Shin Wook | - |
dc.contributor.affiliatedAuthor | Ko, Kwang Il | - |
dc.contributor.affiliatedAuthor | Lee, Mi Jung | - |
dc.contributor.affiliatedAuthor | Kim, Dong Wook | - |
dc.rights.accessRights | not free | - |
dc.citation.volume | 61 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 899 | - |
dc.citation.endPage | 909 | - |
dc.identifier.bibliographicCitation | AMERICAN JOURNAL OF KIDNEY DISEASES, Vol.61(6) : 899-909, 2013 | - |
dc.identifier.rimsid | 29227 | - |
dc.type.rims | ART | - |
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