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Modulation of the Transcriptional Activity of Peroxisome Proliferator-Activated Receptor Gamma by Protein-Protein Interactions and Post-Translational Modifications

Authors
 Tae-Hyun Kim  ;  Mi-Young Kim  ;  Seong-Ho Jo  ;  Joo-Man Park  ;  Yong-Ho Ahn 
Citation
 YONSEI MEDICAL JOURNAL, Vol.54(3) : 545-559, 2013 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2013
MeSH
Gene Expression Regulation ; Homeostasis ; Models, Genetic* ; PPAR gamma/genetics ; PPAR gamma/metabolism ; PPAR gamma/physiology* ; Protein Processing, Post-Translational* ; Sumoylation ; Transcription Factors/metabolism ; Transcription Factors/physiology ; Ubiquitination
Keywords
PPARγ ; adipogenesis ; coregulator ; metabolic syndrome ; post-translational modifications ; transcriptional activity
Abstract
Peroxisome proliferator-activated receptor gamma (PPARγ) belongs to a nuclear receptor superfamily; members of which play key roles in the control of body metabolism principally by acting on adipose tissue. Ligands of PPARγ, such as thiazolidinediones, are widely used in the treatment of metabolic syndromes and type 2 diabetes mellitus (T2DM). Although these drugs have potential benefits in the treatment of T2DM, they also cause unwanted side effects. Thus, understanding the molecular mechanisms governing the transcriptional activity of PPARγ is of prime importance in the development of new selective drugs or drugs with fewer side effects. Recent advancements in molecular biology have made it possible to obtain a deeper understanding of the role of PPARγ in body homeostasis. The transcriptional activity of PPARγ is subject to regulation either by interacting proteins or by modification of the protein itself. New interacting partners of PPARγ with new functions are being unveiled. In addition, post-translational modification by various cellular signals contributes to fine-tuning of the transcriptional activities of PPARγ. In this review, we will summarize recent advancements in our understanding of the post-translational modifications of, and proteins interacting with, PPARγ, both of which affect its transcriptional activities in relation to adipogenesis.
Files in This Item:
T201301442.pdf Download
DOI
10.3349/ymj.2013.54.3.545
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Biochemistry and Molecular Biology (생화학-분자생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Young(김미영)
Kim, Tae Hyun(김태현)
Park, Joo Man(박주만)
Ahn, Yong Ho(안용호) ORCID logo https://orcid.org/0000-0002-4133-0757
Jo, Seong Ho(조성호)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86815
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