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MicroRNA in the Diseased Pulmonary Vasculature: Implications for the Basic Scientist and Clinician

Authors
 Richard C. Jin ; Pil-Ki Min ; Stephen Y. Chan 
Citation
 대한고혈압학회지, Vol.19(1) : 1~16, 2013 
Journal Title
 대한고혈압학회지 
ISSN
 2233-8136 
Issue Date
2013
Abstract
Since the first descriptions of their active functions more than ten years ago, small non-coding RNA species termed microRNA (miRNA) have emerged as essential regulators in a broad range of adaptive and maladaptive cellular processes. With an exceptionally rapid pace of discovery in this field, the dysregulation of many individual miRNAs has been implicated in the development and progression of various cardiovascular diseases. MiRNA are also expected to play crucial regulatory roles in the progression of pulmonary vascular diseases such as pulmonary hypertension (PH), yet direct insights in this field are only just emerging. This review will provide an overview of pulmonary hypertension and its molecular mechanisms, tailored for both basic scientists studying pulmonary vascular biology and physicians who manage PH in their clinical practice. We will describe the pathobiology of pulmonary hypertension and mechanisms of action of miRNA relevant to this disease. Moreover, we will summarize the potential roles of miRNA as biomarkers and therapeutic targets as well as future strategies for defining the cooperative actions of these powerful effectors in pulmonary vascular disease.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86667
DOI
10.5646/jksh.2013.19.1.1
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Internal Medicine
Yonsei Authors
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