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Effects of Uterine Manipulation on Surgical Outcomes in Laparoscopic Management of Endometrial Cancer: A Prospective Randomized Clinical Trial

Authors
 Lee, Maria  ;  Kim, Young Tae  ;  Kim, Sang Wun  ;  Kim, Sunghoon  ;  Kim, Jae Hoon  ;  Nam, Eun Ji 
Citation
 International Journal of Gynecological Cancer, Vol.23(2) : 372-379, 2013 
Journal Title
 International Journal of Gynecological Cancer 
ISSN
 1048-891X 
Issue Date
2013
Abstract
OBJECTIVE: This study aimed to evaluate the influence of intrauterine manipulation on the surgical outcome in patients with early-stage endometrial cancer treated with 2 different laparoscopic approaches. METHODS: In a randomized parallel trial, 110 patients with clinical stage I endometrial cancer were randomly assigned for laparoscopic staging surgery with (group A, 55) or without (group B, 55) the use of a uterine manipulator (RUMI), between June 2009 and June 2011. Two sets of peritoneal washings were obtained, 1 before and 1 after the insertion of the uterine manipulator. Primary end points were the rates of positive cytology and lymphovascular space invasion. RESULTS: No difference was detected in patient characteristics between the groups. Mean operative time, estimated blood loss, and postoperative complications were similar between the groups. Group A had a similar incidence of lymphovascular space invasion compared with group B (12.7% vs 9.1%, respectively; P = 0.761). Four patients (7.3%) in group A had positive peritoneal cytology in the initial washing. One of these patients was classified as stage IIIA. One patient in group B was positive in the second washing. The agreement rate between the 2 sets of washings for both groups was 98.2%. During the median follow-up of 19 months, 6 patients had tumor recurrence without significant difference between the groups. CONCLUSIONS: Despite concerns that the use of uterine manipulators may predispose the spread of early-stage disease, insertion of such uterine-manipulating systems did not increase rate of positive peritoneal cytology or lymphovascular space invasion in this study.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86639
Full Text
http://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00009577-201302000-00025&LSLINK=80&D=ovft
DOI
10.1097/IGC.0b013e3182788485
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실)
Yonsei Authors
김상운(Kim, Sang Wun) ORCID logo https://orcid.org/0000-0002-8342-8701
김성훈(Kim, Sung Hoon)
김영태(Kim, Young Tae) ORCID logo https://orcid.org/0000-0002-7347-1052
김재욱(Kim, Jae Wook)
남은지(Nam, Eun Ji)
이마리아(Lee, Maria)
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