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A nationwide seroepidemiology of hepatitis C virus infection in South Korea

Authors
 Do Young Kim  ;  In Hee Kim  ;  Sook-Hyang Jeong  ;  Yong Kyun Cho  ;  Joon Hyoek Lee  ;  Young-Joo Jin  ;  Don Lee  ;  Dong Jin Suh  ;  Kwang-Hyub Han  ;  Neung Hwa Park  ;  Ha Yan Kang  ;  Young Kul Jung  ;  Young Seok Kim0  ;  Kyung-Ah Kim  ;  Youn Jae Lee  ;  Byung Seok Lee  ;  Hyung Joon Yim  ;  Heon Ju Lee  ;  Soon Koo Baik  ;  Won Young Tak  ;  Sun Jae Lee  ;  Woo Jin Chung  ;  Sung-Kyu Choi0  ;  Eun-Young Cho  ;  Jeong Heo  ;  Dong Joon Kim  ;  Byung-Cheol Song  ;  Man Woo Kim  ;  Jun Lee  ;  Hee Bok Chae  ;  Dae Hee Choi  ;  Hwa Young Choi  ;  Moran Ki 
Citation
 Liver International, Vol.33(4) : 586-594, 2013 
Journal Title
 Liver International 
ISSN
 1478-3223 
Issue Date
2013
Abstract
BACKGROUND & AIMS: The aim of this study was to reveal nationwide seroprevalence of HCV infection in South Korea by a large-scale survey. METHODS: From January to December 2009, a total of 291 314 adults underwent health check-up in 29 centres nationwide. The data concerning anti-HCV antibody and biochemical tests were obtained from all participants. Among subjects with positive anti-HCV, such data as HCV RNA, genotypes and treatment detail were additionally analysed. RESULTS: Using an estimated 2009 population of Korea, the age, sex and area-adjusted anti-HCV positive rate was 0.78%. Anti-HCV prevalence in female patients (0.83%) was higher than that in male patients (0.75%). Gradual increase in anti-HCV positivity was observed, from 0.34% in those aged 20-29 years to 2.31% in those >70 years. The age- and sex-adjusted anti-HCV prevalence varied in different areas, being higher in Busan and Jeonnam (1.53-2.07%), mid-level in Seoul and surrounding districts (0.50-0.61%) and lower in Jeju (0.23%). The comparative analysis of laboratory variables between anti-HCV (+) and anti-HCV (-) group revealed significantly higher levels of alanine aminotransferase and lower levels of serum lipids in anti-HCV (+) group. Among 1 718 anti-HCV positive subjects, serum HCV RNA was measured only in 478 people, of whom 268 (56.1%) patients had detectable HCV RNA in serum. Among 50 patients for whom assessment of response to antiviral therapy was feasible, overall sustained virological response was achieved in 84% of patients. CONCLUSION: The prevalence of HCV infection is low in South Korea. Studies to analyse risk factors are warranted to reduce HCV infection.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86619
DOI
10.1111/liv.12108
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김도영(Kim, Do Young) ; 한광협(Han, Kwang Hyup)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/liv.12108/abstract
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