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Contributing Factors on Lymph Node Yield after Surgery for Mid-Low Rectal Cancer

 Young Jae Ahn  ;  Hye Youn Kwon  ;  Yoon Ah Park  ;  Seung-Kook Sohn  ;  Kang Young Lee 
 Yonsei Medical Journal, Vol.54(2) : 389-395, 2013 
Journal Title
 Yonsei Medical Journal 
Issue Date
PURPOSE: The purpose of the present study was to evaluate the contributing factors to the lymph node status as well as to define the impact of preoperative concurrent chemoradiotherapy (CCRT) on the number of lymph nodes retrieved in mid-low rectal cancer. MATERIALS AND METHODS: We retrospectively analyzed 277 patients who underwent curative surgical resection for mid-low rectal cancer between 1998 and 2007. Eighty-two patients received long course preoperative CCRT followed by surgery. RESULTS: A mean of 13.12±9.28 lymph nodes was retrieved. In a univariate analysis, distance from the anal verge, pT stage, pN stage, lymphovascular invasion, preoperative CCRT had significant influence on the number of lymph nodes retrieved. In a multivariate model, patients in the CCRT group had fewer retrieved lymph nodes than the non-CCRT group (p<0.001). Both univariate and multivariate analyses showed that the ypN0 group had fewer retrieved lymph nodes than the ypN1-2 group (p=0.027) in the CCRT group. CONCLUSION: Preoperative CCRT was an independent risk factor for failure to harvest an appropriate number of lymph nodes, and node-negative patients who received CCRT had fewer lymph nodes harvested.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실)
Yonsei Authors
권혜연(Kwon, Hye Youn)
손승국(Sohn, Seung Kook)
안영재(Ahn, Young Jae)
이강영(Lee, Kang Young)
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