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Contributing Factors on Lymph Node Yield after Surgery for Mid-Low Rectal Cancer

Authors
 Young Jae Ahn  ;  Hye Youn Kwon  ;  Yoon Ah Park  ;  Seung-Kook Sohn  ;  Kang Young Lee 
Citation
 YONSEI MEDICAL JOURNAL, Vol.54(2) : 389-395, 2013 
Journal Title
 YONSEI MEDICAL JOURNAL 
ISSN
 0513-5796 
Issue Date
2013
MeSH
Adult ; Aged ; Aged, 80 and over ; Chemoradiotherapy/methods* ; Female ; Humans ; Lymph Node Excision* ; Lymph Nodes/pathology ; Lymph Nodes/surgery* ; Lymphatic Metastasis/pathology ; Male ; Middle Aged ; Multivariate Analysis ; Neoplasm Staging ; Preoperative Period ; Prognosis ; Rectal Neoplasms/pathology ; Rectal Neoplasms/surgery* ; Retrospective Studies ; Risk Factors
Keywords
Rectal neoplasm ; lymph node ; neoadjuvant therapy
Abstract
PURPOSE: The purpose of the present study was to evaluate the contributing factors to the lymph node status as well as to define the impact of preoperative concurrent chemoradiotherapy (CCRT) on the number of lymph nodes retrieved in mid-low rectal cancer. MATERIALS AND METHODS: We retrospectively analyzed 277 patients who underwent curative surgical resection for mid-low rectal cancer between 1998 and 2007. Eighty-two patients received long course preoperative CCRT followed by surgery. RESULTS: A mean of 13.12±9.28 lymph nodes was retrieved. In a univariate analysis, distance from the anal verge, pT stage, pN stage, lymphovascular invasion, preoperative CCRT had significant influence on the number of lymph nodes retrieved. In a multivariate model, patients in the CCRT group had fewer retrieved lymph nodes than the non-CCRT group (p<0.001). Both univariate and multivariate analyses showed that the ypN0 group had fewer retrieved lymph nodes than the ypN1-2 group (p=0.027) in the CCRT group. CONCLUSION: Preoperative CCRT was an independent risk factor for failure to harvest an appropriate number of lymph nodes, and node-negative patients who received CCRT had fewer lymph nodes harvested.
Files in This Item:
T201300687.pdf Download
DOI
10.3349/ymj.2013.54.2.389
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Hye Youn(권혜연)
Sohn, Seung Kook(손승국)
Ahn, Young Jae(안영재)
Lee, Kang Young(이강영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86573
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