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Role of FGF receptors as an emerging therapeutic target in lung squamous cell carcinoma

Authors
 Sun Min Lim  ;  Hye Ryun Kim  ;  Hyo Sup Shim  ;  Ross A Soo  ;  Byoung Chul Cho 
Citation
 Future Oncology, Vol.9(3) : 377-386, 2013 
Journal Title
 Future Oncology 
ISSN
 1479-6694 
Issue Date
2013
Abstract
Recent advances in molecular medicine and high-throughput sequencing technologies have achieved major cancer strategies and therapeutics over the past decades. For example, identification of oncogenic EGF receptor mutations that are present in up to 20% of lung adenocarcinoma patients confer exquisite sensitivity to EGF receptor inhibitors. However, currently known 'druggable' targets are enriched in the subgroup of adenocarcinomas and individuals who have never smoked. We present an overview of FGFs and FGF receptor (FGFR) signaling in cancer, and the role of FGFR1 as a novel druggable target in lung squamous cell carcinoma. FGFR1 amplification in lung squamous cell carcinoma is required for the survival of FGFR1-amplified cell lines. Currently, clinical reagents that target the FGFs and FGFRs are being developed accordingly. This review focuses on the emerging role of FGFR1 as a therapeutic target in lung squamous cell carcinoma and reviews current agents that are in clinical development for the treatment of FGFR-dependent cancer.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86501
DOI
10.2217/fon.12.190
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김혜련(Kim, Hye Ryun) ; 심효섭(Shim, Hyo Sup) ; 임선민(Lim, Sun Min) ; 조병철(Cho, Byoung Chul)
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Full Text
http://www.futuremedicine.com/doi/abs/10.2217/fon.12.190?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
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