2 190

Cited 375 times in

Randomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.

 Jeong Heo  ;  Tony Reid  ;  Leyo Ruo  ;  Caroline J Breitbach  ;  Steven Rose  ;  Mark Bloomston  ;  Mong Cho  ;  Ho Yeong Lim  ;  Hyun Cheol Chung  ;  Chang Won Kim  ;  James Burke  ;  Riccardo Lencioni  ;  Theresa Hickman  ;  Anne Moon  ;  Yeon Sook Lee  ;  Mi Kyeong Kim  ;  Manijeh Daneshmand  ;  Kara Dubois  ;  Lara Longpre  ;  Minhtran Ngo  ;  Cliona Rooney  ;  John C Bell  ;  Byung-Geon Rhee  ;  Richard Patt  ;  Tae-Ho Hwang  ;  David H Kirn 
 NATURE MEDICINE, Vol.19(3) : 329-336, 2013 
Journal Title
Issue Date
Oncolytic viruses and active immunotherapeutics have complementary mechanisms of action (MOA) that are both self amplifying in tumors, yet the impact of dose on subject outcome is unclear. JX-594 (Pexa-Vec) is an oncolytic and immunotherapeutic vaccinia virus. To determine the optimal JX-594 dose in subjects with advanced hepatocellular carcinoma (HCC), we conducted a randomized phase 2 dose-finding trial (n=30). Radiologists infused low- or high-dose JX-594 into liver tumors (days 1, 15 and 29); infusions resulted in acute detectable intravascular JX-594 genomes. Objective intrahepatic Modified Response Evaluation Criteria in Solid Tumors (mRECIST) (15%) and Choi (62%) response rates and intrahepatic disease control (50%) were equivalent in injected and distant noninjected tumors at both doses. JX-594 replication and granulocyte-macrophage colony-stimulating factor (GM-CSF) expression preceded the induction of anticancer immunity. In contrast to tumor response rate and immune endpoints, subject survival duration was significantly related to dose (median survival of 14.1 months compared to 6.7 months on the high and low dose, respectively; hazard ratio 0.39; P=0.020). JX-594 demonstrated oncolytic and immunotherapy MOA, tumor responses and dose-related survival in individuals with HCC.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.