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The effect of oral prostaglandin analogue on painful diabetic neuropathy: a double-blind, randomized, controlled trial

Authors
 S. Shin  ;  K. J. Kim  ;  H. -J. Chang  ;  B. -W. Lee  ;  W. -I. Yang  ;  B. -S. Cha  ;  D. Choi 
Citation
 Diabetes Obesity & Metabolism, Vol.15(2) : 185-188, 2013 
Journal Title
 Diabetes Obesity & Metabolism 
ISSN
 1462-8902 
Issue Date
2013
Abstract
This study was performed to assess the efficacy of beraprost sodium (BPS) in painful diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM) patients. In this randomized clinical trial, 99 T2DM patients (41% male, age 60 ± 6 years) with DPN but without evidence of peripheral artery disease were randomized to receive either BPS (40 µg, tid) or placebo for 8 weeks. The primary end point was the improvement of the total symptom score (TSS), temperature rebound (TR) and nadir to peak (NP) above baseline. After 8 weeks treatment, the change of TSS in the BPS group showed a significant improvement compared to the placebo group (2.80 ± 2.48 vs. 1.60 ± 1.94 points, p = 0.009). Furthermore, the number of patients who showed signs of improvement in TSS and the proportion of patients with 50% relief of symptom was also significantly greater in the BPS group than in the placebo group (83.7 vs. 62%, p = 0.015, 36.2 vs. 14%, p = 0.009, respectively). In conclusion, treatment with BPS significantly improved TSS over an 8-week period.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/dom.12010/abstract
DOI
10.1111/dom.12010
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
김광준(Kim, Kwang Joon) ORCID logo https://orcid.org/0000-0002-5554-8255
신상훈(Shin, Sang Hoon)
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
이병완(Lee, Byung Wan) ORCID logo https://orcid.org/0000-0002-9899-4992
장혁재(Chang, Hyuck Jae) ORCID logo https://orcid.org/0000-0002-6139-7545
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
최동훈(Choi, Dong Hoon) ORCID logo https://orcid.org/0000-0002-2009-9760
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86407
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