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Coexistence of mupirocin and antiseptic resistance in methicillin-resistant Staphylococcus aureus isolates from Korea

 Hyukmin Lee  ;  Hwansub Lim  ;  Il Kown Bae  ;  Dongeun Yong  ;  Seok Hoon Jeong  ;  Kyungwon Lee  ;  Yunsop Chong 
 Diagnostic Microbiology and Infectious Disease, Vol.75(3) : 308-312, 2013 
Journal Title
 Diagnostic Microbiology and Infectious Disease 
Issue Date
Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents, Local/pharmacology* ; Antiporters/genetics ; Bacterial Proteins/genetics ; Bacterial Typing Techniques/methods ; Drug Resistance, Multiple, Bacterial* ; Genes, Bacterial ; Humans ; Incidence ; Membrane Transport Proteins/genetics ; Methicillin-Resistant Staphylococcus aureus/classification ; Methicillin-Resistant Staphylococcus aureus/drug effects* ; Methicillin-Resistant Staphylococcus aureus/genetics ; Microbial Sensitivity Tests ; Multilocus Sequence Typing ; Mupirocin/pharmacology* ; Nuclear Proteins/genetics ; Republic of Korea/epidemiology ; Staphylococcal Infections/epidemiology* ; Tertiary Care Centers
Mupirocin ; Antiseptics ; Resistance ; MRSA
In this study, we determined the prevalence of mupirocin and antiseptics resistance in methicillin-resistant Staphylococcus aureus (MRSA) at a secondary- and a tertiary-care hospital in Korea. Mupirocin susceptibility test, ileS gene sequencing, and polymerase chain reaction for mupA, qacA/B, and smr gene were performed with 456 nonduplicated MRSA isolates collected from 2 hospitals in Korea. Genetic relatedness was determined by spa typing and multilocus sequence typing (MLST). The rates of low-level and high-level mupirocin resistance were 7% and 2% in the secondary-care hospital and 17% and 2% in the tertiary-care hospital, respectively. The positive rate of qacA/B and smr gene in mupirocin-resistant MRSA was 65% and 71%, respectively. In spa typing, most mupirocin-resistant MRSA showed genetic relatedness and some of the highly resistant isolates were ST239 and ST5 in MLST analysis. The distribution of low-level and high-level mupirocin resistance and the coexistence of antiseptic resistance in MRSA can result in failure of decolonization in Korea.
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1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Bae, Il Kwon(배일권)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Lee, Kyungwon(이경원) ORCID logo https://orcid.org/0000-0003-3788-2134
Jeong, Seok Hoon(정석훈) ORCID logo https://orcid.org/0000-0001-9290-897X
Chong, Yun Sop(정윤섭)
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