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Coexistence of mupirocin and antiseptic resistance in methicillin-resistant Staphylococcus aureus isolates from Korea

Authors
 Hyukmin Lee ; Hwansub Lim ; Yunsop Chong ; Kyungwon Lee ; Seok Hoon Jeong ; Dongeun Yong ; Il Kown Bae 
Citation
 Diagnostic Microbiology and Infectious Disease, Vol.75(3) : 308~312, 2013 
Journal Title
 Diagnostic Microbiology and Infectious Disease 
ISSN
 0732-8893 
Issue Date
2013
Abstract
In this study, we determined the prevalence of mupirocin and antiseptics resistance in methicillin-resistant Staphylococcus aureus (MRSA) at a secondary- and a tertiary-care hospital in Korea. Mupirocin susceptibility test, ileS gene sequencing, and polymerase chain reaction for mupA, qacA/B, and smr gene were performed with 456 nonduplicated MRSA isolates collected from 2 hospitals in Korea. Genetic relatedness was determined by spa typing and multilocus sequence typing (MLST). The rates of low-level and high-level mupirocin resistance were 7% and 2% in the secondary-care hospital and 17% and 2% in the tertiary-care hospital, respectively. The positive rate of qacA/B and smr gene in mupirocin-resistant MRSA was 65% and 71%, respectively. In spa typing, most mupirocin-resistant MRSA showed genetic relatedness and some of the highly resistant isolates were ST239 and ST5 in MLST analysis. The distribution of low-level and high-level mupirocin resistance and the coexistence of antiseptic resistance in MRSA can result in failure of decolonization in Korea.
URI
http://ir.ymlib.yonsei.ac.kr/handle/22282913/86374
DOI
10.1016/j.diagmicrobio.2012.11.025
Appears in Collections:
1. 연구논문 > 1. College of Medicine > Dept. of Laboratory Medicine
Yonsei Authors
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Link
 http://www.sciencedirect.com/science/article/pii/S0732889312005202
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