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Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles

Authors
 Sun-Mi Lee  ;  Hyung Joon Kim  ;  Kyung-Hwa Yoo  ;  Yong-Beom Park  ;  Soo-Kon Lee  ;  Young Nyun Park  ;  You-Jung Ha 
Citation
 ACS Nano, Vol.7(1) : 50-57, 2013 
Journal Title
 ACS Nano 
ISSN
 1936-0851 
Issue Date
2013
Abstract
We have developed RGD-attached gold (Au) half-shell nanoparticles containing methotrexate (MTX) for the treatment of rheumatoid arthritis (RA), where MTX is the most widely used disease-modifying anti-rheumatic drug (DMARD) for the treatment of RA, and RGD peptide is a targeting moiety for inflammation. Upon near-infrared (NIR) irradiation, heat is locally generated due to Au half-shells, and the drug release rate is enhanced, delivering heat and drug to the inflamed joints simultaneously. RA is a chronic inflammatory disease characterized by synovial inflammation in multiple joints within the penetration depth of NIR light. When combined with NIR irradiation, these nanoparticles containing a much smaller dosage of MTX (1/930 of MTX solution) showed greater therapeutic effects than that of a conventional treatment with MTX solution in collagen-induced arthritic mice. This novel drug delivery system is a good way to maximize therapeutic efficacy and minimize dosage-related MTX side effects in the treatment of RA. Furthermore, these multifunctional nanoparticles could be applied to other DMARDs for RA or other inflammatory diseases.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86361
DOI
10.1021/nn301215q
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
Yonsei Authors
박영년(Park, Young Nyun) ; 박용범(Park, Yong Beom) ; 이수곤(Lee, Soo Kon) ; 하유정(Ha, You Jung)
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Full Text
http://pubs.acs.org/doi/abs/10.1021/nn301215q
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