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Targeted chemo-photothermal treatments of rheumatoid arthritis using gold half-shell multifunctional nanoparticles

Authors
 Sun-Mi Lee  ;  Hyung Joon Kim  ;  You-Jung Ha  ;  Young Nyun Park  ;  Soo-Kon Lee  ;  Yong-Beom Park  ;  Kyung-Hwa Yoo 
Citation
 ACS NANO, Vol.7(1) : 50-57, 2013 
Journal Title
 ACS NANO 
ISSN
 1936-0851 
Issue Date
2013
MeSH
Animals ; Antirheumatic Agents/administration & dosage ; Arthritis, Rheumatoid/therapy* ; Combined Modality Therapy ; Gold/therapeutic use* ; Hyperthermia, Induced/methods* ; Metal Nanoparticles/chemistry ; Metal Nanoparticles/therapeutic use* ; Methotrexate/administration & dosage* ; Mice ; Nanocapsules/administration & dosage* ; Phototherapy/methods* ; Treatment Outcome
Keywords
chemo-photothermal treatment ; multifunctional nanoparticles ; NIR resonance ; photothermally controlled drug delivery ; rheumatoid arthritis
Abstract
We have developed RGD-attached gold (Au) half-shell nanoparticles containing methotrexate (MTX) for the treatment of rheumatoid arthritis (RA), where MTX is the most widely used disease-modifying anti-rheumatic drug (DMARD) for the treatment of RA, and RGD peptide is a targeting moiety for inflammation. Upon near-infrared (NIR) irradiation, heat is locally generated due to Au half-shells, and the drug release rate is enhanced, delivering heat and drug to the inflamed joints simultaneously. RA is a chronic inflammatory disease characterized by synovial inflammation in multiple joints within the penetration depth of NIR light. When combined with NIR irradiation, these nanoparticles containing a much smaller dosage of MTX (1/930 of MTX solution) showed greater therapeutic effects than that of a conventional treatment with MTX solution in collagen-induced arthritic mice. This novel drug delivery system is a good way to maximize therapeutic efficacy and minimize dosage-related MTX side effects in the treatment of RA. Furthermore, these multifunctional nanoparticles could be applied to other DMARDs for RA or other inflammatory diseases.
Full Text
http://pubs.acs.org/doi/abs/10.1021/nn301215q
DOI
10.1021/nn301215q
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Park, Yong Beom(박용범)
Lee, Soo Kon(이수곤)
Ha, You Jung(하유정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86361
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