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Is progressive upper-body apraxia a corticobasal syndrome?

Authors
 Hae-Won Shin  ;  Sook-keun Song  ;  Young H. Sohn 
Citation
 JOURNAL OF CLINICAL NEUROSCIENCE, Vol.20(2) : 319-322, 2013 
Journal Title
JOURNAL OF CLINICAL NEUROSCIENCE
ISSN
 0967-5868 
Issue Date
2013
MeSH
Aged ; Apraxias/complications ; Apraxias/diagnosis* ; Arm/pathology* ; Atrophy ; Basal Ganglia Diseases/complications ; Basal Ganglia Diseases/diagnosis* ; Humans ; Male ; Middle Aged ; Neurodegenerative Diseases/complications ; Neurodegenerative Diseases/diagnosis ; Supranuclear Palsy, Progressive/complications ; Supranuclear Palsy, Progressive/diagnosis* ; Syndrome
Keywords
Corticobasal degeneration ; Focal cortical atrophy ; Upper-body apraxia
Abstract
Corticobasal degeneration (CBD) is characterized by various clinical manifestations including corticobasal syndrome, progressive supranuclear palsy-like syndrome and frontotemporal dementia. Focal cortical atrophy syndrome as the initial manifestation rarely occurs in CBD. Here, we present a 62-year-old man and a 70-year-old man who were admitted due to clumsiness in the arms. On initial neurological examination, they showed asymmetric limb apraxia without parkinsonism or global cognitive dysfunction. Brain MRI showed focal atrophy in the frontal and prefrontal cortices, and brain positron emission tomography scan revealed decreased metabolism in these same brain locations. Although these patients developed parkinsonism and dystonia within several years, the neurological signs were limited to the arms for a long period. "Progressive upper-body apraxia" may be a rare clinical manifestation of CBD which shows a benign clinical outcome. The patients described may enhance our understanding of the clinical heterogeneity of this disease.
Full Text
http://www.sciencedirect.com/science/article/pii/S0967586812003530
DOI
10.1016/j.jocn.2012.02.029
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
Song, Sook Keun(송숙근)
Shin, Hye Won(신혜원)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86296
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