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Effect of a single bolus injection of low-dose hydrocortisone for prevention of atrial fibrillation recurrence after radiofrequency catheter ablation

 Hoyoun Won  ;  Jong-Youn Kim  ;  Jaemin Shim  ;  Jae-Sun Uhm  ;  Hui-Nam Pak  ;  Moon-Hyoung Lee  ;  Boyoung Joung 
 CIRCULATION JOURNAL, Vol.77(1) : 53-59, 2013 
Journal Title
Issue Date
Adult ; Aged ; Anti-Inflammatory Agents/administration & dosage* ; Anti-Inflammatory Agents/adverse effects ; Atrial Fibrillation/prevention & control* ; Catheter Ablation* ; Female ; Follow-Up Studies ; Humans ; Hydrocortisone/administration & dosage* ; Hydrocortisone/adverse effects ; Male ; Middle Aged ; Secondary Prevention ; Time Factors
Atrial fibrillation ; Catheter ablation ; Corticosteroid ; Recurrence
BACKGROUND: The transient use of corticosteroid shortly after atrial fibrillation (AF) ablation might prevent immediate and mid-term AF recurrence; however, the effective dosage for preventing AF recurrence has not been determined. In this study, we evaluated whether low-dose hydrocortisone is effective for the prevention of AF recurrence after radiofrequency catheter ablation (RFCA). METHODS AND RESULTS: We enrolled 89 AF patients (70 males, 55.8 ± 10.9 years) who underwent RF ablation and were treated with single bolus injection of 100mg hydrocorticosteroid (corticosteroid group). For the control group, we enrolled 120 sex- and age-matched AF patients (94 males, 55.4 ± 10.5 years). Pericarditis occurred in 3 (2.5%) and 1 (1.1%) patients in the control and corticosteroid groups, respectively. The number of patients with immediate AF recurrence (≤ 2 days) was 17 (14.5%) and 11 (12.4%) in the control and steroid groups, respectively (P=0.687). Treatment with low-dose steroid did not decrease early (3-30 days) AF recurrence (13 [11.1%] vs. 11 [12.5%], P=0.829) or late (≥ 31 days) AF recurrence after ablation (26 [22.2%] vs. 13 [14.6%], P=0.209). There was no difference in cumulative survival free of late AF recurrence between the corticosteroid and control groups (P=0.57 by log-rank test). White blood cell count, C-reactive protein concentration and maximum body temperature also were unchanged by low-dose steroid. CONCLUSIONS: Single bolus injection of low-dose hydrocortisone after AF ablation is not effective for preventing AF recurrence during the mid-term follow-up period.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Youn(김종윤) ORCID logo https://orcid.org/0000-0001-7040-8771
Pak, Hui Nam(박희남) ORCID logo https://orcid.org/0000-0002-3256-3620
Shim, Jae Min(심재민)
Uhm, Jae Sun(엄재선) ORCID logo https://orcid.org/0000-0002-1611-8172
Won, Ho Youn(원호연)
Lee, Moon Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
Joung, Bo Young(정보영) ORCID logo https://orcid.org/0000-0001-9036-7225
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