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Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions

Authors
 Hannah Seok  ;  Eun Young Lee  ;  Eun Yeong Choe  ;  Woo In Yang  ;  Joo Young Kim  ;  Dong Yeob Shin  ;  Ho Jin Cho  ;  Tae Sung Kim  ;  Mi Jin Yun  ;  Jong Doo Lee  ;  Eun Jig Lee  ;  Sung-Kil Lim  ;  Yumie Rhee 
Citation
 Korean Journal of Internal Medicine, Vol.28(1) : 81-88, 2013 
Journal Title
 Korean Journal of Internal Medicine 
ISSN
 1226-3303 
Issue Date
2013
Abstract
Background/Aims Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions. Methods 18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed. Results Of 24 patients with piuitary adenomas, 19 (79.2%) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50%) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7% sensitivity and 100% specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans. Conclusions About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.
Files in This Item:
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DOI
10.3904/kjim.2013.28.1.81
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Seok, Hannah(석한나)
Shin, Dong Yeob(신동엽) ORCID logo https://orcid.org/0000-0003-1048-7978
Yang, Woo Ick(양우익) ORCID logo https://orcid.org/0000-0002-6084-5019
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
Rhee, Yumie(이유미) ORCID logo https://orcid.org/0000-0003-4227-5638
Lee, Eun Young(이은영)
Lee, Eun Jig(이은직) ORCID logo https://orcid.org/0000-0002-9876-8370
Lee, Jong Doo(이종두)
Lim, Sung Kil(임승길)
Choe, Eun Yeong(최은영)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86239
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