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Analysis of 18F-fluorodeoxyglucose positron emission tomography findings in patients with pituitary lesions

 Hannah Seok  ;  Eun Young Lee  ;  Yumie Rhee  ;  Sung-Kil Lim  ;  Eun Jig Lee  ;  Jong Doo Lee  ;  Mi Jin Yun  ;  Tae Sung Kim  ;  Ho Jin Cho  ;  Dong Yeob Shin  ;  Joo Young Kim  ;  Woo In Yang  ;  Eun Yeong Choe 
 Korean Journal of Internal Medicine, Vol.28(1) : 81-88, 2013 
Journal Title
 Korean Journal of Internal Medicine 
Issue Date
Background/Aims Although magnetic resonance imaging (MRI) is a good visual modality for the evaluation of pituitary lesions, it has limited value in the diagnosis of mixed nodules and some cystic lesions. We evaluated the usefulness of 18F-fluorodeoxyglucose positron emission tomography (FDG PET) for patients with pituitary lesions. Methods 18F-FDG PET and MRI were performed simultaneously in 32 consecutive patients with pituitary lesions. The relationships between FDG uptake patterns in PET and MRI findings were analyzed. Results Of 24 patients with piuitary adenomas, 19 (79.2%) showed increased uptake of 18F-FDG in the pituitary gland on PET scans. All patients with pituitary macroadenomas showed increased 18F-FDG uptake on PET scans. Meanwhile, only five (50%) of the 10 patients with pituitary microadenomas showed positive PET scans. Interestingly, of two patients with no abnormal MRI findings, one showed increased 18F-FDG uptake on PET. For positive 18F-FDG uptake, maximum standardized uptake values (SUVmax) > 2.4 had 94.7% sensitivity and 100% specificity. In addition, SUVmax increased in proportion to the size of pituitary adenomas. Most cystic lesions did not show 18F-FDG uptake on PET scans. Conclusions About 80% of pituitary adenomas showed positivity on PET scans, and SUVmax was related to the size of the adenomas. PET may be used as an ancillary tool for detection and differentiation of pituitary lesions.
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
석한나(Seok, Hannah) ; 신동엽(Shin, Dong Yeob) ; 양우익(Yang, Woo Ick) ; 윤미진(Yun, Mi Jin) ; 이유미(Rhee, Yumie) ; 이은영(Lee, Eun Young) ; 이은직(Lee, Eun Jig) ; 이종두(Lee, Jong Doo) ; 임승길(Lim, Sung Kil) ; 최은영(Choe, Eun Yeong)
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