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Metabolism-Related Proteins Are Differentially Expressed according to the Molecular Subtype of Invasive Breast Cancer Defined by Surrogate Immunohistochemistry

 Junjeong Choi  ;  Woo-Hee Jung  ;  Ja Seung Koo 
 PATHOBIOLOGY, Vol.80(1) : 41-52, 2013 
Journal Title
Issue Date
Adult ; Antigens, Neoplasm/metabolism* ; Biomarkers, Tumor/metabolism* ; Breast Neoplasms/metabolism* ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Carbonic Anhydrase IX ; Carbonic Anhydrases/metabolism* ; Carcinoma, Ductal, Breast/metabolism* ; Carcinoma, Ductal, Breast/mortality ; Carcinoma, Ductal, Breast/pathology ; Female ; Gene Expression Regulation, Neoplastic ; Glucose Transporter Type 1/metabolism* ; Glycolysis ; Humans ; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism ; Immunohistochemistry ; Immunophenotyping ; Intramolecular Oxidoreductases/metabolism ; Macrophage Migration-Inhibitory Factors/metabolism ; Middle Aged ; Neoplasm Grading ; Neoplasm Staging ; Prognosis ; Protein-Serine-Threonine Kinases/metabolism ; Receptor, ErbB-2/metabolism ; Survival Rate ; Tissue Array Analysis
Aerobic glycolysis ; Breast cancer ; CAIX ; Glut-1
OBJECTIVE: The purpose of this study was to investigate the expression of metabolism-related proteins such as Glut-1 and carbonic anhydrase IX (CAIX) according to breast cancer molecular subtype. METHODS: We generated a tissue microarray of 276 breast cancer patients and performed immunohistochemical staining for known metabolism-related proteins, which were evaluated according to the molecular subtype. RESULTS: The expression of IGF-1, MIF, and HIF-1α was correlated with the HER-2 type (p < 0.05). Glut-1 overexpression and CAIX expression were associated with TNBC type, especially with basal-like type, high histologic grade, estrogen receptor negativity, and progesterone receptor negativity (p < 0.05). The expression of Glut-1 and CAIX was correlated with statistical significance (p < 0.001). CONCLUSION: We identified different patterns of expression of metabolism-related proteins according to the molecular subtypes of breast cancer defined by surrogate immunohistochemistry. Increased expression of HIF-1α, IGF-1, and MIF was noted in HER-2 type breast cancer and increased expression of Glut-1 and CAIX was noted in TNBC type breast cancer, especially in the basal-like subtype, which exhibited a glycolytic and acid-resistant tumor phenotype.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Jung, Woo Hee(정우희)
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