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Clinical characteristics of eosinophilic and noneosinophilic asthma in children

Authors
 Yong Ju Lee  ;  Kyung Won Kim  ;  Kyu-Earn Kim  ;  Myung Hyun Sohn  ;  Bong Seok Choi 
Citation
 Acta Paediatrica, Vol.102(1) : 53-57, 2013 
Journal Title
 Acta Paediatrica 
ISSN
 0803-5253 
Issue Date
2013
Abstract
AIM: Asthma is a heterogeneous and complex chronic inflammatory disease of the airways. Asthma can be classified as eosinophilic asthma (EA) or noneosinophilic asthma (NEA). We investigated whether children with EA manifest different clinical characteristics than those with NEA. METHODS: We enrolled 288 steroid-naive asthmatic children and classified them, based on the cell counts in induced sputum, into EA (158 children) and NEA (89 children) groups. RESULTS: No significant differences were observed between the groups with regard to age, sex, family history of atopy, secondary smoking or asthma exacerbations. Moderate-to-severe asthma was more frequent in the EA group than in the NEA group. Blood eosinophil counts and serum eosinophil cationic protein were higher in EA patients than in NEA patients. The forced expiratory volume in 1 sec was lower in children with EA than in those with NEA (% of predicted value, 88.6 ± 18.5 vs. 93.6 ± 15.6, p < 0.05). The sputum eosinophil (in EA) and neutrophil (in NEA) counts increased with increasing asthma severity. CONCLUSION: Airway inflammation, especially eosinophilic inflammation, was associated with asthma severity and reduced pulmonary function in children
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/86168
DOI
10.1111/apa.12046
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실)
Yonsei Authors
김경원(Kim, Kyung Won) ; 김규언(Kim, Kyu Earn) ; 손명현(Son, Myung Hyun)
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Full Text
http://onlinelibrary.wiley.com/doi/10.1111/apa.12046/abstract
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