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Akt1 as a putative regulator of Hox genes

DC FieldValueLanguage
dc.contributor.author공경아-
dc.contributor.author김명희-
dc.date.accessioned2014-12-18T08:20:47Z-
dc.date.available2014-12-18T08:20:47Z-
dc.date.issued2013-
dc.identifier.issn0378-1119-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/86135-
dc.description.abstractIn mammals, precise spatiotemporal expressions of Hox genes control the main body axis during embryogenesis. However, the mechanism by which Hox genes are regulated is poorly understood. To discover the putative regulator of Hox genes, in silico analyses were performed using GEO profiles, and Akt1 emerged as a candidate regulator of Hox genes in E13.5 MEFs. The results of the RT-PCR showed that 5′ Hoxc genes, including ncRNA were upregulated in Akt1 null MEF. Combined bisulfite restriction analysis (COBRA) and bisulfite sequencing showed that the CpG island of a 5′ Hoxc gene was hypomethylated in Akt1 null cells. These results indicate that Hox expression could be controlled by the function of Akt1 through epigenetic modification such as DNA methylation.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfGene-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCells, Cultured-
dc.subject.MESHComputer Simulation-
dc.subject.MESHCpG Islands-
dc.subject.MESHDNA Methylation-
dc.subject.MESHFibroblasts-
dc.subject.MESHGene Expression Regulation-
dc.subject.MESHGenes, Homeobox*-
dc.subject.MESHGenes, Regulator*-
dc.subject.MESHMice-
dc.subject.MESHProto-Oncogene Proteins c-akt/genetics*-
dc.subject.MESHProto-Oncogene Proteins c-akt/metabolism-
dc.subject.MESHReverse Transcriptase Polymerase Chain Reaction-
dc.subject.MESHUp-Regulation-
dc.titleAkt1 as a putative regulator of Hox genes-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anatomy (해부학)-
dc.contributor.googleauthorKyoung-Ah Kong-
dc.contributor.googleauthorHeejei Yoon-
dc.contributor.googleauthorMyoung Hee Kim-
dc.identifier.doi10.1016/j.gene.2012.10.034-
dc.admin.authorfalse-
dc.admin.mappingfalse-
dc.contributor.localIdA00158-
dc.contributor.localIdA00432-
dc.relation.journalcodeJ00921-
dc.identifier.pmid23154063-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0378111912013121-
dc.subject.keywordHox gene-
dc.subject.keywordAkt1-
dc.subject.keywordIn silico analysis-
dc.subject.keywordDNA methylation-
dc.contributor.alternativeNameKong, Kyoung Ah-
dc.contributor.alternativeNameKim, Myoung Hee-
dc.contributor.affiliatedAuthorKong, Kyoung Ah-
dc.contributor.affiliatedAuthorKim, Myoung Hee-
dc.rights.accessRightsnot free-
dc.citation.volume513-
dc.citation.number2-
dc.citation.startPage287-
dc.citation.endPage291-
dc.identifier.bibliographicCitationGene, Vol.513(2) : 287-291, 2013-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers

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