A structured framework for standardized 3D leg alignment analysis: An international Delphi consensus study

Veerman, Quinten W. T.; Tuijthof, Gabriëlle J. M.; Verdonschot, Nico; Brouwer, Reinoud W.; Verdonk, Peter; van Haver, Annemieke; van der Veen, Hugo C.; Pijpker, Peter A. J.; Heuvel, Judith olde; Hoogeslag, Roy A. G.; Erdemir, Ahmet; Perrier, Antoine; Sigrist, Bastian; Innocenti, Bernardo; Imhauser, Carl W.; Belvedere, Claudio; Vuurberg, Gwendolyn; Weinans, Harrie; Fürmetz, Julian; Carman, Laura; Blankevoort, Leendert; Taylor, Mark; Donnez, Mathias; Feucht, Matthias J.; Ollivier, Matthieu; Hirschmann, Michael T.; Jung, Min; Tanoğlu, Oguzhan; Niemeyer, Philipp; Khakha, Raghbir; Custers, Roel J. H.; van Heerwaarden, Ronald; Kuiper, Ruurd J. A.; Fucentese, Sandro F.; Claes, Steven; Besier, Thor F.; León-Muñoz, Vicente J.; Petersen, Wolf; van Genechten, Wouter; Teng, Yuanjun

doi:10.1002/ksa.12676

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A structured framework for standardized 3D leg alignment analysis: An international Delphi consensus study

Authors: Veerman, Quinten W. T. ; Tuijthof, Gabriëlle J. M. ; Verdonschot, Nico ; Brouwer, Reinoud W. ; Verdonk, Peter ; van Haver, Annemieke ; van der Veen, Hugo C. ; Pijpker, Peter A. J. ; Heuvel, Judith olde ; Hoogeslag, Roy A. G. ; Erdemir, Ahmet ; Perrier, Antoine ; Sigrist, Bastian ; Innocenti, Bernardo ; Imhauser, Carl W. ; Belvedere, Claudio ; Vuurberg, Gwendolyn ; Weinans, Harrie ; Fürmetz, Julian ; Carman, Laura ; Blankevoort, Leendert ; Taylor, Mark ; Donnez, Mathias ; Feucht, Matthias J. ; Ollivier, Matthieu ; Hirschmann, Michael T. ; Jung, Min ; Tanoğlu, Oguzhan ; Niemeyer, Philipp ; Khakha, Raghbir ; Custers, Roel J. H. ; van Heerwaarden, Ronald ; Kuiper, Ruurd J. A. ; Fucentese, Sandro F. ; Claes, Steven ; Besier, Thor F. ; León-Muñoz, Vicente J. ; Petersen, Wolf ; van Genechten, Wouter ; Teng, Yuanjun

Citation: Knee Surgery, Sports Traumatology, Arthroscopy, Vol.33(6) : 2276-2292, 2025-06

Journal Title: KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

ISSN: 0942-2056

Issue Date: 2025-06

MeSH: Consensus ; Delphi Technique ; Femur* / anatomy & histology ; Femur* / diagnostic imaging ; Humans ; Imaging, Three-Dimensional* ; Knee Joint* / anatomy & histology ; Knee Joint* / diagnostic imaging ; Knee Joint* / surgery ; Models, Anatomic ; Tibia* / anatomy & histology ; Tibia* / diagnostic imaging

Keywords: alignment parameters ; consensus ; coordinate systems ; joint orientation ; knee

Abstract: Purpose: To reach consensus among international experts on a structured framework for standardized 3D leg alignment analysis based on 3D bone models, ensuring consistency and improving clinical applicability. Methods: A Delphi study was performed in four rounds. Rounds 1 and 2 involved a steering and rating group that developed statements based on principles preserving the 3D complexity of anatomical structures, identified through a systematic review. These statements encompassed approaches for deriving joint centres and joint orientations, and defining coordinate systems using 3D bone models. In Rounds 3 and 4, a panel of 35 international experts, including clinicians (54%) and engineers (46%), with participants from Europe (80%), Oceania (9%), Asia (6%), and the Americas (6%), evaluated these statements. Consensus was defined as ≥80% agreement. Results: Rounds 1 and 2 resulted in 31 statements to be included in the survey. Of these, 26 achieved consensus in Round 3, with the five remaining statements refined and reaching consensus in Round 4. Experts agreed on utilising all available relevant surface data to define joint centres, joint orientations, and individual femoral and tibial coordinate systems alongside a combined leg coordinate system, and adopting central 3D axes for femoral version and tibial torsion. Conclusions: This international Delphi consensus study provides a structured framework for a standardized 3D leg alignment analysis based on 3D bone models. This framework aims to enhance clinical applicability for preoperative planning and execution of uni- and multiplanar correction osteotomies around the knee, reduce the methodological variability in 3D leg alignment analysis literature, and improve cross-study comparability. Level of Evidence: Level V. © 2025 The Author(s). Knee Surgery, Sports Traumatology, Arthroscopy published by John Wiley & Sons Ltd on behalf of European Society of Sports Traumatology, Knee Surgery and Arthroscopy.