Recommendation for use of 15- and 20-valent pneumococcal

Abstract

Pneumococcal disease remains the leading cause of mor bidity in young children worldwide. Recent advances have expanded pneumococcal conjugate vaccines (PCVs) beyond 13valent (PCV13) to 15valent (PCV15) and 20 valent (PCV20) vaccines, which add 2 and 7 serotypes, respectively, thereby broadening their potential protec tive effects against invasive pneumococcal disease (IPD). Although policies vary among countries, Korea incorpo rated PCV15 and PCV20 into its National Immunization Program for children in April 2024 and October 2025, respectively, an implementation that is considered within the context of global epidemiology and policy trends. This review discusses evidence of the immunogenicity and safety of PCV15 and PCV20 from clinical trials and early postlicensure data, examines the serotype distribution and IPD burden in Korea alongside data from other re gions, and summarizes vaccination recommendations for healthy and high risk pediatric populations, including considerations for catchup, interchangeability, and their coadministration. By integrating national updates and global evidence, this review aims to support clinicians and policymakers worldwide optimizing pneumococcal vaccination strategies for children.