The Effective Delivery of Poly(D,L-lactic Acid) (Juvelook) via Needle-Free Injection (CUREJET) for Facial Rejuvenation

Abstract

Background Poly(D,L-lactic acid) (PDLLA) is increasingly used for skin rejuvenation, utilizing innovative delivery systems like needle-free injectors to enhance patient comfort and efficacy. Objective To evaluate the clinical efficacy and safety of PDLLA delivered through a microjet injector and to assess the durability of its rejuvenating effect over 24 weeks. Methods This study involved 40 patients who underwent five treatment sessions of PDLLA (Juvelook) treatment via a needle-free microjet system. Efficacy was assessed through clinical evaluation (GAIS), patient satisfaction surveys, and 3D imaging analysis at baseline, 8 weeks, and 24 weeks. Results GAIS scores improved from 1.48 +/- 0.32 at baseline to 1.90 +/- 0.28 at 8 weeks and 2.16 +/- 0.26 at 24 weeks (p < 0.001). Patient satisfaction increased from 3.38 +/- 1.12 to 7.95 +/- 0.86 (8 weeks) and 8.71 +/- 0.69 (24 weeks). 3D imaging showed progressive vector displacement, with a mean displacement of 1.5 +/- 0.4 mm at 8 weeks and 2.3 +/- 0.5 mm at 24 weeks, indicating sustained lifting and textural improvement. These effects are attributed to the high-velocity microjet delivery mechanism, which enables uniform intradermal dispersion with minimal trauma. Conclusion PDLLA (Juvelook) delivered via needle-free injection (CUREJET, BAZ BIOMEDIC CO., LTD.) is a safe and effective modality for facial rejuvenation, offering a promising alternative to conventional methods. Further research is needed to explore long-term outcomes and mechanistic insights.