이상운동질환 환자에서의 소화기계 증상에 대한 관리: 파킨슨병을 
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이상운동질환 환자에서의 소화기계 증상에 대한 관리: 파킨슨병을 중심으로

Other Titles: Management of Gastrointestinal Symptoms in Patients with Movement Disorders: Focusing on Parkinson's Disease

Authors: 이정윤 ; 김경민 ; 김병수 ; 김승우 ; 김희진 ; 백경원 ; 석진명 ; 선우준상 ; 송인욱 ; 우호걸 ; 이익성 ; 정진만 ; 최교민 ; 최윤호 ; 고성범 ; 양광익 ; 대한신경과학회 진료지침위원회

Citation: Journal of the Korean Neurological Association (대한신경과학회지), Vol.43(4) : 222-232, 2025-11

MeSH: Parkinson disease ; Constipation ; Gastroparesis ; Sialorrhea ; Brain-gut axis

Keywords: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease. While PD is typically characterized by motor symptoms such as bradykinesia, tremor, rigidity, postural instability, and gait disturbances, patients frequently present numerous non-motor symptoms, including gastrointestinal manifestations. These gastrointestinal symptoms may be fundamentally related to alpha-synuclein pathology, and dopaminergic treatments may further contribute to reduced gastrointestinal motility. Gastrointestinal symptoms can occur before the diagnosis of PD and at any stage during the disease course, affecting the gastrointestinal tract from the oral cavity to the anus. If left untreated, gastrointestinal problems can impair medication absorption, leading to motor fluctuations and potentially causing complications such as malnutrition and aspiration pneumonia, which may be life-threatening. Therefore, clinicians should not overlook gastrointestinal symptoms in PD patients. Gastrointestinal symptoms in PD can manifest diversely throughout the entire disease course, requiring healthcare providers to recognize these symptoms and provide individualized management. Since current treatments for PD-related gastrointestinal symptoms are largely derived from data in non-PD patients, future research and clinical guideline development in this f ield are required for establishing evidence-based care protocols.