Assessment of concurrent neoplasms and a paraneoplastic association in MOGAD

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Authors: Kwon, Young Nam ; Tisavipat, Nanthaya ; Guo, Yong ; Syc-Mazurek, Stephanie B. ; Han, Ji Yeon ; Kim, Jun-Soon ; Choi, Kyomin ; Oh, Seong-il ; Choi, Seok-Jin ; Sohn, Eunhee ; Oh, Jeeyoung ; Kim, Seung Woo ; Shin, Ha Young ; Lim, Byung Chan ; Kim, Byoung Joon ; Park, Kyung Seok ; Sung, Jung-Joon ; Kim, Se Hoon ; Park, Sung-Hye ; Zekeridou, Anastasia ; Lucchinetti, Claudia F. ; Pittock, Sean J. ; Chen, John J. ; Flanagan, Eoin P. ; Kim, Sung-Min

Citation: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY(Ann Clin Transl Neurol), Vol.12(4) : 861-870, 2025-04

Journal Title: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY(Ann Clin Transl Neurol)

MeSH: Adult ; Aged ; Aged, 80 and over ; Autoantibodies ; Demyelinating Autoimmune Diseases, CNS* / complications ; Demyelinating Autoimmune Diseases, CNS* / epidemiology ; Demyelinating Autoimmune Diseases, CNS* / immunology ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease ; Myelin-Oligodendrocyte Glycoprotein* / immunology ; Neoplasms* / epidemiology ; Republic of Korea / epidemiology ; Retrospective Studies ; United States / epidemiology ; Young Adult

Keywords: Autoantibodies ; Myelin-oligodendrocyte Glycoprotein ; Envision Flex ; Spss Version 26 For Windows ; Adolescent ; Adult ; Article ; Brain Tissue ; Cancer Tissue ; Child ; Cohort Analysis ; Concurrent Neoplasm ; Disease Duration ; Female ; Follow Up ; Glioblastoma ; Histopathology ; Human ; Human Tissue ; Immunohistochemistry ; Major Clinical Study ; Male ; Malignant Neoplasm ; Multicenter Study ; Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease ; Paraneoplastic Syndrome ; Retrospective Study ; Standardized Incidence Ratio ; Aged ; Autoimmune Demyelinating Disease Of The Central Nervous System ; Complication ; Epidemiology ; Immunology ; Incidence ; Middle Aged ; Neoplasm ; South Korea ; United States ; Very Elderly ; Young Adult ; Autoantibody ; Myelin Oligodendrocyte Glycoprotein ; Adult ; Aged ; Aged, 80 And Over ; Autoantibodies ; Demyelinating Autoimmune Diseases, Cns ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease ; Myelin-oligodendrocyte Glycoprotein ; Neoplasms ; Republic Of Korea ; Retrospective Studies ; Young Adult

Abstract: Cases of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) co-occurring with neoplasms have been reported. In this international, retrospective cohort study in South Korea and the USA, 16 of 445 (3.6%) patients with MOGAD had concurrent neoplasm within 2 years of MOGAD onset, resulting in a standardized incidence ratio for neoplasm of 3.10 (95% confidence interval [CI], 1.77-4.81; P < 0.001) when compared to the age- and country-adjusted incidence of neoplasm in the general population. However, none of the nine tumor tissues obtained demonstrated MOG immunostaining. The slightly increased frequency without immunohistopathological evidence suggest with true paraneoplastic MOGAD is extremely rare.