근치적 절제술을 시행한 바터씨 팽대부암에서 Ki-67과 VEGF의 예후인자로서의 가능성

Abstract

Purpose: Ampulla of Vater cancer has a more favorable prognosis and survival than other 이우정, 지훈상malignant periampullary tumors. The pathologic staging of ampulla of Vater carcinoma is a keydeterminant of the patient’s prognosis. However, we have often encountered patients in whomthe course of their disease differed substantially from what would be predicted based on theirclinical staging, which highlights the need to consider additional predictive factors. We applied animmunohistochemical technique to examine the expression of Ki-67 and VEGF in radicallyresectedampulla of Vater carcinomas, and then compared the status of expression with severalclinicopathologic factors.Methods: Sixty-four patients who underwent curative resection for ampulla of Vater cancerbetween January 1992 and December 2006 at the Yonsei University College of Medicine werereviewed. The relationships between the expression of molecular markers and clinicopathologicfactors were determined.Results: There was no relationship between the clinicopathologic characteristics and theexpression of molecular markers in patients with ampulla of Vater cancer. Among theclinicopathologic characteristics, lymph node metastasis was identified as an independent factorof survival after curative resection for ampulla of Vater carcinoma.Conclusion: Measurement of Ki-67 and VEGF in patients with ampulla of Vater carcinoma mayhave an important role in identifying the poor prognostic group.