췌장 신경 내분비 종양의 외과적 경험 - 기능성과 비 기능성 종양의 비교 연구

Abstract

Background: Aims A neuroendocrine neoplasm (NEN) of the pancreas is rare, and can bedivided into functioning and nonfunctioning NEN. This study was carried out to determine thecharacteristics and surgical outcomes of NEN of the pancreas experienced in a single institution.Methods: The medical records of patients diagnosed with NEN of the pancreas (pancreaticislet-cell neoplasm) between June 1900 and June 2005 were retrospectively reviewed.Results: A total of 33 patients with NEN of the pancreas were examined. Nineteen patients(57.6%) had a nonfunctioning NEN and 14 (42.4%) had a functioning NEN. By comparison, thetumor size (p=0.001), distant metastasis (p=0.042), malignant characteristics (p=0.010) andsurvival (p=0.002), were significantly different. Surgical resections were almost always possiblein the cases of functioning NEN. Patients with functioning NENs of the pancreas had asignificantly higher survival than those patients with nonfunctioning NENs (p=0.002). A curativeresection provided a better survival outcome in patients with nonfunctioning NENs (p=0.005) andoffered a more than 80% disease-free survival in those with functioning NENs of the pancreas.Conclusion: Nonfunctioning NENs of the pancreas appeared to be more aggressive thanfunctioning NENs. A complete resection of the NENs of the pancreas can provide a goodprognosis.