3 24

Cited 0 times in

2024 KSoLA Update on New Lipid-Lowering Agents: Inclisiran and Bempedoic Acid

Authors
 Hack-Lyoung Kim  ;  Jung-Joon Cha  ;  Sang-Hak Lee  ;  Clinical Practice Guidelines Committee  ;  Korean Society of Lipid and Atherosclerosis (KSoLA) 
Citation
 Journal of Lipid and Atherosclerosis, Vol.14(2) : 135-144, 2025-05 
Journal Title
Journal of Lipid and Atherosclerosis
ISSN
 2287-2892 
Issue Date
2025-05
Keywords
Coronary artery disease ; Lipoproteins ; Pharmacology ; Safety
Abstract
Inclisiran and bempedoic acid (BA) are non-statin lipid-lowering agents that have been approved for use in the US and Europe. Inclisiran, a subcutaneously administered small interfering RNA targeting proprotein convertase subtilisin/kexin type 9 messenger RNA, is effectively delivered to the liver via lipid nanoparticles and conjugation. In several phase 3 trials, it has successfully reduced low-density lipoprotein cholesterol (LDL-C) by 50% and has an acceptable safety profile. Currently, the results of clinical outcome studies are awaited. While it is indicated for both primary and secondary cardiovascular prevention, it is selectively recommended after statin-based regimens. BA, an oral inhibitor of adenosine triphosphate-citrate lyase, decreases cholesterol production and enhances LDL uptake by hepatocytes. This enzyme is absent in muscle cells, and BA has fewer muscle-related adverse events. In clinical trials, it lowered LDL-C by 17%-21% compared to placebo and showed a clinical outcome benefit in patients with statin intolerance. This agent modestly increases the incidence of gout and cholelithiasis. For primary and secondary prevention, it may be recommended as a non-first-line agent, either alone or in combination therapy.
Files in This Item:
T202503708.pdf Download
DOI
10.12997/jla.2025.14.2.135
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/206235
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links