This study aimed to evaluate and compare the color stability between 3D-printed resin-based artificial teeth and conventional commercial artificial teeth when exposed to various staining agents, including Korean traditional red pepper paste. Three types of resin-based artificial teeth were used: 3D-printed teeth using NextDent C&B material and two conventional commercial products (Biotone® and Livera Anterio®). The specimens (n=120) were immersed in distilled water (control), coffee, red pepper paste, and Trypan blue for periods of 1, 3, and 5 weeks. Color measurements were performed using a spectrophotometer (VITA Easyshade®V) to record L*, a*, and b* values. Color differences (ΔE00) were calculated using the CIEDE2000 formula. Statistical analysis was performed using one-way ANOVA with Tukey’s post-hoc test (p<0.05). NextDent C&B artificial teeth showed significantly higher ΔE00 values compared to commercial artificial teeth in all staining agents (p<0.05). The largest color changes were observed in the order of red pepper paste, coffee, Trypan blue, and distilled water for all specimens. After 5 weeks of immersion, NextDent C&B exhibited ΔE00 values exceeding the clinically acceptable threshold (ΔE00 ≤4.1) in both red pepper paste (8.0±1.4) and coffee (6.6±1.0) solutions. In contrast, commercial artificial teeth maintained ΔE00 values below 4.1 in all staining agents throughout the study period. 3D-printed artificial teeth demonstrated inferior color stability compared to conventional commercial artificial teeth, particularly when exposed to red pepper paste and coffee. The results suggest that current 3D-printed resin-based artificial teeth require improvements in color stability before clinical application.