Clinical Validation of Face-Fit Surface-Lighting Micro Light-Emitting Diode Mask for Skin Anti-Aging Treatment

Abstract

Photobiomodulation therapy based on micro light-emitting diodes (mu LEDs) holds remarkable potential for the beauty industry. Here, a cosmetically effective face-fit surface-lighting mu LED mask for skin anti-aging is introduced. The face-conformable mask enables deep tissue treatment through proximal light irradiation, with a 3D origami structure capable of adapting to complex facial contours with closed adherence. A blister-assisted laser transfer achieves rapid and accurate mu LEDs transfer at a high throughput of 50 chips per second, facilitating a mass-producible and large-area process. Finally, clinical trials demonstrate significant improvements in elasticity, sagging, and wrinkles across six facial areas, with a maximum enhancement of 340% in deep skin elasticity of the perioral area compared to the conventional LED mask group. This work demonstrates a flexible, wearable light-emitting device for skin anti-aging. The mask, based on a 3D origami structure, achieves conformal contact with the face, maximizing phototherapeutic effects. Notably, improvements in the elasticity of deep skin were 340% greater compared to a conventional LED mask. The blister-actuated laser-induced transfer achieves a 99.61% yield for microLEDs at a rate of 50 chips per second, enabling mass production. image