Skull base surgery for malignant tumors: The 2nd international collaborative study (1995-2015)

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Authors: Jatin P Shah ; Helena Levyn ; Cristina Valero ; Dauren Adilbay ; Alana Eagan ; Junting Zheng ; Mithat Gonen ; Marc Cohen ; Snehal Patel ; Ian Ganly ; Prathamesh Pai ; Paolo Castelnuovo ; Fang Ju Gao ; Cesare Piazza ; Piero Nicolai ; Ben Panizza ; James Bowman ; Catherine Barnett ; Luiz P Kowalski 8 ; Ronaldo Toledo ; Dan M Fliss ; John DeAlmeida ; Ian Witterick ; Philippe Herman ; Walter Fontanella ; Gregorio Sanchez Aniceto ; Sefik Hosal ; Serdar Ozer ; Subramania Iyer ; Richard Harvey ; C Rene Leemans ; Jan-Jaap Hendrickx ; Marcelo Figari ; Luis Boccalatte ; Ken Ichi Nibu ; Peter Clarke ; Catherine Rennie ; Zhu Yi Ming ; Claudio Cernea ; Sergio Goncalves ; Rodney Schlosser ; Fernando Dias ; Zoukaa Sargi ; Shahzada Ahmed ; Wojciech Golusinski ; Se Heon Kim ; Shirley Y Su ; Shaan M Raza ; Franco DeMonte ; Ehab Hanna

Citation: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.46(11) : 2762-2775, 2024-11

Journal Title: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

MeSH: Adult ; Aged ; Endoscopy ; Female ; Humans ; International Cooperation ; Male ; Middle Aged ; Neurosurgical Procedures / methods ; Prognosis ; Retrospective Studies ; Skull Base Neoplasms* / mortality ; Skull Base Neoplasms* / pathology ; Skull Base Neoplasms* / surgery ; Treatment Outcome

Keywords: global collaboration ; multimodality treatment ; prognostic factors ; skull base tumors ; survival outcomes

Abstract: Background: The current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.

Patients and methods: A total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.

Results: The median age was 56 years (IQR 44-67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow-up of 7.1 years, the 5-year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.

Conclusion: The progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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