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Risk assessment of hepatitis B virus-related hepato-cellular carcinoma development using vibration-controlled transient elastography: Systematic review and meta-analysis

Authors
 Young-Joo Jin  ;  Hee Yeon Kim  ;  Young Ju Suh  ;  Chae Hyeon Lee  ;  Jung Hwan Yu  ;  Mi Na Kim  ;  Ji Won Han  ;  Han Ah Lee  ;  Jihyun An  ;  Young Eun Chon  ;  Dae Won Jun  ;  Miyoung Choi  ;  Seung Up Kim 
Citation
 CLINICAL AND MOLECULAR HEPATOLOGY, Vol.30(Suppl) : S159-S171, 2024-09 
Journal Title
CLINICAL AND MOLECULAR HEPATOLOGY
ISSN
 2287-2728 
Issue Date
2024-09
MeSH
Carcinoma, Hepatocellular* / epidemiology ; Carcinoma, Hepatocellular* / pathology ; Carcinoma, Hepatocellular* / virology ; Elasticity Imaging Techniques* / methods ; Hepatitis B virus ; Hepatitis B, Chronic* / complications ; Hepatitis B, Chronic* / diagnostic imaging ; Hepatitis B, Chronic* / pathology ; Hepatitis B, Chronic* / virology ; Humans ; Liver Neoplasms* / epidemiology ; Liver Neoplasms* / pathology ; Liver Neoplasms* / virology ; Risk Assessment ; Vibration*
Keywords
Chronic hepatitis B ; Hepatocellular carcinoma ; Liver stiffness measurement ; Vibration-controlled transient elastography
Abstract
Backgrounds/aims: Liver stiffness measurement (LSM) using vibration-controlled transient elastography (VCTE) can assess fibrotic burden in chronic liver diseases. The systematic review and meta-analysis was conducted to determine whether LSM using VCTE can predict the risk of development of hepatocellular carcinoma (HCC) in chronic hepatitis B (CHB) patients.

Methods: A systematic literature search of the Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases (from January 2010 to June 2023) was conducted. Of the 1,345 individual studies identified, 10 studies that used VCTE were finally registered. Hazard ratios (HRs) and the 95% confidence intervals (CIs) were considered summary estimates of treatment effect sizes of ≥11 kilopascal (kPa) standard for HCC development. Meta-analysis was performed using the restricted Maximum Likelihood random effects model.

Results: Among the ten studies, data for risk ratios for HCC development could be obtained from nine studies. When analyzed for the nine studies, the HR for HCC development was high at 3.33 (95% CI, 2.45-4.54) in CHB patients with a baseline LSM of ≥11 kPa compared to patients who did not. In ten studies included, LSM of ≥11 kPa showed the sensitivity and specificity for predicting HCC development were 61% (95% CI, 50-71%) and 78% (95% CI, 66-86%), respectively, and the diagnostic accuracy was 0.74 (95% CI, 0.70-0.77).

Conclusion: The risk of HCC development was elevated in CHB patients with VCTE-determined LSM of ≥11 kPa. This finding suggests that VCTE-determined LSM values may aid the risk prediction of HCC development in CHB patients.
Files in This Item:
T992024823.pdf Download
DOI
10.3350/CMH.2024.0163
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Mi Na(김미나)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/202389
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