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Photodynamic and Photothermal therapy via human serum albumin delivery

Authors
 Xuechen Li  ;  Xinyue Li  ;  Suyoung Park  ;  Shining Wu  ;  Yongxian Guo  ;  Ki Taek Nam d, Nahyun Kwon  ;  Juyoung Yoon  ;  Qiongzheng Hu 
Citation
 Coordination Chemistry Reviews, Vol.520 : 216142, 2024-12 
Journal Title
 Coordination Chemistry Reviews 
Issue Date
2024-12
Keywords
Photodynamic therapy (PDT) ; Photothermal therapy (PTT) ; Human serum albumin (HSA) ; Photosensitizer ; Photothermal converting agent (PTCA)
Abstract
Phototherapy, which mainly includes photodynamic therapy (PDT) and photothermal therapy (PTT), is a new type of tumor therapy that uses a specific light source to irradiate enriched phototherapy drugs at the tumor site and produce reactive oxygen species or induce a photothermal action to kill the tumor. Human serum albumin (HSA)—the most abundant carrier protein in serum—has diverse binding domains; thus, it can be used as a carrier to bind various photosensitizers and photothermal converting agents (PTCAs) to improve the therapeutic efficacy of PDT and PTT. Compared to traditional tumor therapy, phototherapy administered via HSA delivery has the advantages of strong targeting and less trauma and has been widely studied to date. However, this interesting topic has not yet been systematically reviewed. Herein, we focus on the recent research progress on photosensitizers and PTCAs in HSA-delivered PDT and PTT, including their design and synthesis, tumor-targeting mechanisms, and tumor therapeutic applications. Furthermore, as clinical tumor treatment methods, PDT and PTT still have several drawbacks and limitations, such as the inability to spread to metastatic tumors, the dependence on the dose of photosensitizers and PTCAs, low light tissue penetration, and the requirement to avoid light for patients during treatment. This important review may facilitate the development of enhanced photosensitizers and PTCAs to provide highly powerful research tools for basic medical studies aimed at improving the diagnosis and treatment of clinical cancer.
Full Text
https://www.sciencedirect.com/science/article/pii/S0010854524004880
DOI
10.1016/j.ccr.2024.216142
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Nam, Ki Taek(남기택)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/202197
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