개인노출평가 기반 PM2.5 흡입량에 따른 노출환경별 노출양상과 호기산화질소와의 연관성

Abstract

Exposure to fine particle (PM2.5, particles with an aerodynamic diameter≤2.5 μm) has been demonstrated to be associated with adverse health effects, including local and systemic inflammation in the body, lung function decline and increases in mortality and morbidity of cardiopulmonary diseases. Fractional exhaled nitrogen oxide (FeNO) is a non-invasive surrogate marker of airway inflammation and chronic airway inflammation is a key characteristic in the pathogenesis of asthma. Existing fine particle exposure evaluation methods were mainly evaluated with air pollution concentration data measured by outdoor air pollution monitoring stations and used measurements from monitoring stations close to the subject’s residence. However, there can be a difference in the geographical location of the measuring station and the geographical location of each individual’s living behavior radius. In this study, exposure assessment was conducted considering individual activity patterns to minimize uncertainties caused by using air pollution measurement data. In this study, the concentration and physical activity of fine particle by micro-environment were measured, the contribution and exposure intensity by micro-environment were calculated based on the average daily fine particle exposure, and the fractional exhaled nitrogen oxide index was repeatedly measured to confirm changes due to fine particle exposure. Exposure contribution by micro-environment was the highest at home (70%). On the other hand, exposure intensity was the highest at job/school (20%). This means that even if the exposure time is short in a real environment, the intensity may appear higher in other environments depending on the inhalation exposure dose. The results of the fractional exhaled nitrogen oxide index due to fine particle exposure showed a significant increase in 1.9% (95% CI: 0.9, 2.9) on 0 lags of time difference when fine particle increased by 10 μg/m3.