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Distinct Cognitive Trajectories According to Amyloid Positivity in Non-Alzheimer Disease Dementias

Authors
 Hyemin Jang  ;  Min Young Chun  ;  Jihwan Yun  ;  Jun Pyo Kim  ;  Sung Hoon Kang  ;  Hee Jin Kim  ;  Duk L Na  ;  Eun Hye Lee  ;  Daeun Shin  ;  Hongki Ham  ;  Yuna Gu  ;  Chi-Hun Kim  ;  Sook-Young Woo  ;  Sang Won Seo  ;  K-ROAD Study Groups 
Citation
 CLINICAL NUCLEAR MEDICINE, Vol.49(12) : 1073-1078, 2024-12 
Journal Title
CLINICAL NUCLEAR MEDICINE
ISSN
 0363-9762 
Issue Date
2024-12
MeSH
Aged ; Aged, 80 and over ; Alzheimer Disease / diagnostic imaging ; Alzheimer Disease / metabolism ; Amyloid / metabolism ; Amyloid beta-Peptides / metabolism ; Apolipoproteins E / genetics ; Cognition ; Dementia* / diagnostic imaging ; Dementia* / metabolism ; Female ; Humans ; Male ; Middle Aged ; Positron-Emission Tomography
Abstract
Background: The clinical effects of β-amyloid positivity (Aβ+) on copathologies in various dementias remain relatively underexamined. Thus, the present study was conducted to investigate the prevalence and clinical effects of Aβ+ in subcortical vascular cognitive impairment (SVCI) and frontotemporal dementia (FTD).

Patients and methods: We enrolled SVCI (n = 583), FTD (n = 152), and cognitively unimpaired (CU) participants (n = 1,249) who underwent Aβ PET scans. The odds of having Aβ+ were subsequently compared among the diagnostic groups (CU, SVCI, and FTD) according to age and apolipoprotein E genotype. Additionally, a linear mixed-effects model was used to investigate the effects of Aβ+ on cognitive trajectories in SVCI and FTD.

Results: Compared with CU, the SVCI group had a higher prevalence of Aβ+ in the 75 to 90 years age group (adjusted odds ratio, 1.97; 95% confidence interval, 1.36-2.85; P < 0.001), as well as within the apolipoprotein E ε3/ε3 group (adjusted odds ratio, 1.78; 95% confidence interval, 1.20-2.63; P = 0.001), whereas the FTD group showed no difference in Aβ+ prevalence. Aβ+ was associated with a worse cognitive trajectory in SVCI (adjusted β-coefficient = -0.6424; P < 0.001), but not in FTD.

Conclusions: These findings contribute to our understanding of Aβ biomarker traits in various dementias in Korea.
Full Text
https://journals.lww.com/nuclearmed/fulltext/2024/12000/distinct_cognitive_trajectories_according_to.1.aspx
DOI
10.1097/RLU.0000000000005457
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Chun, Min Young(전민영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201719
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