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Efficacy of Oral Sulfate Tablet and 2 L-Polyethylene Glycol With Ascorbic Acid for Bowel Preparation: A Prospective Randomized KASID Multicenter Trial

Authors
 Yunho Jung  ;  Hyun Gun Kim  ;  Dong-Hoon Yang  ;  Hyoun Woo Kang  ;  Jae Jun Park  ;  Dong Hoon Baek  ;  Jaeyoung Chun  ;  Tae-Geun Gweon  ;  Hyeon Jeong Goong  ;  Min Seob Kwak  ;  Hyun Jung Lee  ;  Soo-Kyung Park  ;  Jong Hoon Lee 
Citation
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.39(48) : e301, 2024-12 
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
ISSN
 1011-8934 
Issue Date
2024-12
MeSH
Administration, Oral ; Adult ; Ascorbic Acid* / administration & dosage ; Ascorbic Acid* / therapeutic use ; Cathartics* / administration & dosage ; Cathartics* / adverse effects ; Cathartics* / therapeutic use ; Colonoscopy* ; Female ; Humans ; Male ; Middle Aged ; Polyethylene Glycols* / administration & dosage ; Prospective Studies ; Single-Blind Method ; Sulfates / administration & dosage ; Sulfates / therapeutic use ; Tablets*
Keywords
Bowel Preparation ; Colonoscopy ; Polyethylene Glycol ; Sulfate
Abstract
Background: Oral sulfate tablets (OSTs) are bowel preparation agents that combine oral sulfate solution and simethicone. This study compared the efficacy, tolerability, and safety of OST compared to 2 L-polyethylene glycol plus ascorbic acid (2 L-PEG/ASC).

Methods: This prospective, randomized, controlled, single-blinded, multicenter, noninferiority trial enrolled 211 healthy adults who underwent colonoscopy between May 2020 and September 2022 at 13 university hospitals. The bowel cleansing rate was assessed using the Boston Bowel Preparation Scale (BBPS) and Harefield Cleansing Scale (HCS), and the preparation agents were administered in split regimens.

Results: The total BBPS score (8.2 ± 1.5 vs. 7.8 ± 1.4, p = 0.040) and the high-quality bowel cleansing rates in the right colon (73.2% vs. 50.5), transverse colon (80.6% vs. 68.0%), and left colon (81.5% vs. 67.0%) on the BBPS were significantly higher in the OST group than in the 2 L-PEG/ASC group. However, the rates of successful cleansing according to BBPS (90.7% vs. 91.2%) and HCS (96.3% vs. 94.2%) did not significantly differ between the two groups. The taste, ease, and amount of consumption of the preparation agent; and willingness to repeat colonoscopy with the same agent (89.8% vs. 78.6%, P = 0.026) were significantly better in the OST group compared to the 2 L-PEG/ASC group. Adverse events and clinically significant laboratory changes were not significantly different between the two groups.

Conclusion: The OST was not inferior to 2 L-PEG/ASC in terms of bowel cleansing efficacy and showed better tolerability when used for bowel preparation for colonoscopy.

Trial registration: Clinical Research Information Service Identifier: KCT0005017.
Files in This Item:
T202500191.pdf Download
DOI
10.3346/jkms.2024.39.e301
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jae Jun(박재준)
Chun, Jaeyoung(천재영) ORCID logo https://orcid.org/0000-0002-4212-0380
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201653
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