Cited 0 times in

Endoscopic mucosal resection using anchored snare Tip-in versus precut technique for small rectal neuroendocrine tumors

Authors
 Seung Wook Hong  ;  Dong-Hoon Yang  ;  Yoo Jin Lee  ;  Dong Hoon Baek  ;  Jaeyoung Chun  ;  Hyun Gun Kim  ;  Sung Joo Kim  ;  Seung-Mo Hong  ;  Dae-Seong Myung 
Citation
 KOREAN JOURNAL OF INTERNAL MEDICINE, Vol.39(2) : 238-247, 2024-03 
Journal Title
KOREAN JOURNAL OF INTERNAL MEDICINE
ISSN
 1226-3303 
Issue Date
2024-03
MeSH
Endoscopic Mucosal Resection* / adverse effects ; Humans ; Intestinal Mucosa / diagnostic imaging ; Intestinal Mucosa / pathology ; Intestinal Mucosa / surgery ; Neuroendocrine Tumors* / diagnostic imaging ; Neuroendocrine Tumors* / pathology ; Neuroendocrine Tumors* / surgery ; Prospective Studies ; Rectal Neoplasms* / pathology ; Rectal Neoplasms* / surgery ; Retrospective Studies ; Treatment Outcome
Keywords
Endoscopic mucosal resection ; Multicenter study ; Neuroendocrine tumors ; Randomized controlled trial
Abstract
Background/aims: Small rectal neuroendocrine tumors (NETs) can be treated with modified endoscopic mucosal resection (EMR). However, an optimal EMR method remains to be established. We aimed to assess the non-inferiority of Tip-in EMR versus precut EMR (EMR-P) for treating rectal NETs.

Methods: This prospective, multicenter, randomized controlled trial enrolled patients with rectal NETs of < 10 mm in diameter. The patients were randomly assigned to EMR-P and Tip-in EMR groups in a 1:1 ratio. Primary outcome was margin-negative (R0) resection rate between the two methods, with a noninferiority margin of 10%.

Results: Seventy-five NETs in 73 patients, including 64 eligible lesions (32 lesions in each, EMR-P and Tip-in EMR groups), were evaluated. In a modified intention-to-treat analysis, R0 resection rates of the EMR-P and Tip-in EMR groups were 96.9% and 90.6%, respectively, which did not demonstrate non-inferiority (risk difference, -6.3 [95% confidence interval: -18.0 to 5.5]). Resection time in the EMR-P group was longer than that in the Tip-in EMR group (p < 0.001). One case of intraprocedural bleeding was reported in each group.

Conclusion: We did not demonstrate the non-inferiority of Tip-in EMR compared to EMR-P for treating small rectal NETs. However, the R0 resection rates for both techniques were high enough for clinical application.
Files in This Item:
T202500189.pdf Download
DOI
10.3904/kjim.2023.263
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Chun, Jaeyoung(천재영) ORCID logo https://orcid.org/0000-0002-4212-0380
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201652
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links