Cited 0 times in

Immune environment of high-TIL breast cancer: triple negative and hormone receptor positive HER2 negative

Authors
 Su-Jin Shin  ;  Inho Park  ;  Heounjeong Go  ;  Jiwon Ko  ;  Yangkyu Lee  ;  Jee Hung Kim  ;  Sung Gwe Ahn  ;  Joon Jeong  ;  Soong June Bae  ;  Yoon Jin Cha 
Citation
 NPJ BREAST CANCER, Vol.10 : 102, 2024-11 
Journal Title
NPJ BREAST CANCER
Issue Date
2024-11
Abstract
This study explores differences in immune cell (IC) composition and spatial distribution between triple-negative breast cancer (TNBC) and hormone receptor-positive, HER2-negative breast cancer (HR + HER2-BC) in high-TIL (≥60%) cases, focusing on PD-L1 status. Using multiplex immunofluorescence on resected tumor tissues from 18 TNBC and 14 HR + HER2-BC cases, we analyzed IC types (CD20, CD8, CD4, FOXP3) and their spatial interactions. TNBC showed a unique IC composition characterized by a higher proportion of CD8 + IC (stroma: 27% vs 17%, p < 0.001; tumor: 54% vs 31%, p < 0.001) and CD4 + FOXP3 + IC (stroma: 3.9% vs 3.0%, p = 0.036), compared to HR + HER2-BC. Notably, PD-L1 positive TNBC cases demonstrated denser infiltration CD4 + FOXP3 + IC in the stromal region compared to HR + HER2-BC (146.4 ± 67.1/mm2 vs 114.3 ± 146.9/mm2, p = 0.036), along with pronounced IC clustering near TC. Both tumor subtypes displayed varied IC compositions based on PD-L1 status. In conclusion, IC composition and spatial distribution in high-TIL TNBC and HR + HER2-BC significantly differ, influenced by PD-L1 status.
Files in This Item:
T202500158.pdf Download
DOI
10.1038/s41523-024-00712-9
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jee Hung(김지형) ORCID logo https://orcid.org/0000-0002-9044-8540
Park, Inho(박인호)
Bae, Soong June(배숭준) ORCID logo https://orcid.org/0000-0002-0012-9694
Shin, Su Jin(신수진) ORCID logo https://orcid.org/0000-0001-9114-8438
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Lee, Yangkyu(이양규)
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
Cha, Yoon Jin(차윤진) ORCID logo https://orcid.org/0000-0002-5967-4064
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201649
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links