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Ethnic differences in the prevalence of amyloid positivity and cognitive trajectories

Authors
 Hyemin Jang  ;  Min Young Chun  ;  Jihwan Yun  ;  Jun Pyo Kim  ;  Sung Hoon Kang  ;  Michael Weiner  ;  Hee Jin Kim  ;  Duk L Na  ;  Chang-Hyung Hong  ;  Sang Joon Son  ;  Hyun Woong Roh  ;  Tae-Kyeong Lee  ;  Eek-Sung Lee  ;  Eun Hye Lee  ;  Daeun Shin  ;  Hongki Ham  ;  Yuna Gu  ;  Yeshin Kim  ;  Chi-Hun Kim  ;  Sook-Young Woo  ;  Sang Won Seo  ;  ADNI, A4 study, and K‐ROAD study groups 
Citation
 ALZHEIMERS & DEMENTIA, Vol.20(11) : 7556-7566, 2024-11 
Journal Title
ALZHEIMERS & DEMENTIA
ISSN
 1552-5260 
Issue Date
2024-11
MeSH
Aged ; Aged, 80 and over ; Alzheimer Disease* / epidemiology ; Alzheimer Disease* / ethnology ; Amyloid beta-Peptides* / metabolism ; Brain / diagnostic imaging ; Brain / pathology ; Cognitive Dysfunction* / epidemiology ; Cognitive Dysfunction* / ethnology ; Female ; Humans ; Male ; Positron-Emission Tomography* ; Prevalence ; Republic of Korea / epidemiology ; White People*
Keywords
Alzheimer's disease ; amyloid‐β positivity ; cognitive trajectories ; ethnic differences ; positron emission tomography
Abstract
Introduction: We investigated the prevalence of amyloid beta (Aβ) positivity (+) and cognitive trajectories in Koreans and non-Hispanic Whites (NHWs).

Methods: We included 5121 Koreans from multiple centers across South Korea and 929 NHWs from the Alzheimer's Disease Neuroimaging Initiative (ADNI). Participants underwent Aβ positron emission tomography and were categorized into cognitively unimpaired (CU), mild cognitive impairment (MCI), and dementia stages. Age, sex, education, and apolipoprotein E. genotype were adjusted using multivariable logistic regression and stabilized inverse probability of treatment weights based on the propensity scores to mitigate imbalances in these variables.

Results: The prevalence of Aβ+ was lower in CU Koreans than in CU NHWs (adjusted odds ratio 0.60). Aβ+ Koreans showed a faster cognitive decline than Aβ+ NHWs in the CU (B = -0.314, p = .004) and MCI stages (B = -0.385, p < .001).

Discussion: Ethnic characteristics of Aβ biomarkers should be considered in research and clinical application of Aβ-targeted therapies in diverse populations.

Highlights: Koreans have a lower prevalence of Aβ positivity compared to NHWs in the CU stage. The effects of Alzheimer's risk factors on Aβ positivity differ between Koreans and NHWs. Aβ-positive (Aβ+) Koreans show faster cognitive decline than Aβ+ NHWs in the CU and MCI stages.
Files in This Item:
T202407433.pdf Download
DOI
10.1002/alz.14247
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Chun, Min Young(전민영)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/201535
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