Evaluating the Efficacy of Immune Checkpoint Inhibitors in Elderly Patients: A Systematic Review and Meta-analysis

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Citation: Methods in Molecular Biology (Clifton, N.J.), Vol.2857 : 117-125, 2025-03

MeSH: Aged ; Humans ; Immune Checkpoint Inhibitors* / therapeutic use ; Immunotherapy / methods ; Neoplasms* / drug therapy ; Neoplasms* / immunology ; Neoplasms* / mortality ; Progression-Free Survival ; Treatment Outcome

Keywords: Age ; Elderly ; Immune checkpoint inhibitor ; Immunosenescence ; Immunotherapy ; Meta-analysis ; Systematic review ; Systemic reviews

Abstract: In this chapter, we outline the steps for designing and conducting a rigorous systematic review and meta-analysis, focusing on the efficacy of immune checkpoint inhibitors (ICIs) in elderly patients. ICIs have improved survival rates in advanced cancers, yet their effectiveness in older populations remains unclear. We detail the essential processes involved in both systematic reviews and meta-analyses. We can evaluate the efficacy of ICIs in elderly patients with advanced cancer, examining outcomes such as overall survival and progression-free survival.

Appears in Collections:: 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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