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Peripheral cranio-spinal nerve communication for trapezius muscle control using axonal profiling through immunostaining

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dc.contributor.author김신형-
dc.contributor.author양헌무-
dc.date.accessioned2024-12-06T03:57:08Z-
dc.date.available2024-12-06T03:57:08Z-
dc.date.issued2024-10-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/201298-
dc.description.abstractAccessory nerve (CNXI) has been known to be the primary conduit for motor control of the trapezius, while the supplementary cervical nerves (C3 and C4) are responsible for processing sensory information from muscle. However, the lack of substantial direct evidence has led to these conclusions being regarded as mere speculation. This study used immunostaining (using antibodies against neurofilament 200 for all axons, choline acetyltransferase for cholinergic axons, tyrosine hydroxylase for sympathetic axons, and alpha 3 sodium potassium ATPase for proprioceptive afferent axons) of human samples to verify the functional contributions of nerves. Study highlights the pivotal role of C3 and C4 in regulating precise movements of trapezius, contributing to motor control, proprioceptive feedback, and sympathetic modulation. CNXI is composed primarily of somatic efferent fibers, with significant numbers of sympathetic or sensory fibers. Furthermore, C3-4 have both cholinergic and non-cholinergic axons, suggesting their involvement in proprioceptive feedback and somatic efferent functions. Although less common, mechanosensors such as nociceptive sensor and sympathetic fibers are also supplied by these cervical nerves. The study demonstrated that these nerves contain motor fibers and significant proprioceptive and sympathetic axons, challenging the long-held notion that CNXI are motor and upper spinal nerves are sensory.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfSCIENTIFIC REPORTS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAccessory Nerve / metabolism-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAxons* / metabolism-
dc.subject.MESHAxons* / physiology-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProprioception / physiology-
dc.subject.MESHSpinal Nerves / metabolism-
dc.subject.MESHSuperficial Back Muscles* / innervation-
dc.titlePeripheral cranio-spinal nerve communication for trapezius muscle control using axonal profiling through immunostaining-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Anesthesiology and Pain Medicine (마취통증의학교실)-
dc.contributor.googleauthorMiri Kim-
dc.contributor.googleauthorIn-Seung Yeo-
dc.contributor.googleauthorTae-Hyeon Cho-
dc.contributor.googleauthorJu-Eun Hong-
dc.contributor.googleauthorShin Hyung Kim-
dc.contributor.googleauthorHun-Mu Yang-
dc.identifier.doi10.1038/s41598-024-76645-x-
dc.contributor.localIdA00676-
dc.contributor.localIdA02324-
dc.relation.journalcodeJ02646-
dc.identifier.eissn2045-2322-
dc.identifier.pmid39448752-
dc.subject.keywordAccessory nerve-
dc.subject.keywordAxon-
dc.subject.keywordCervical spinal nerves-
dc.subject.keywordImmunofluorescence-
dc.subject.keywordProprioceptive-
dc.subject.keywordTrapezius-
dc.contributor.alternativeNameKim, Shin Hyung-
dc.contributor.affiliatedAuthor김신형-
dc.contributor.affiliatedAuthor양헌무-
dc.citation.volume14-
dc.citation.number1-
dc.citation.startPage25266-
dc.identifier.bibliographicCitationSCIENTIFIC REPORTS, Vol.14(1) : 25266, 2024-10-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anatomy (해부학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers

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