Nano-Drone for T2 Turbo Spin Echo (TSE) MRI In Gastric Cancer Mice Model

Abstract

In the ever-evolving field of Magnetic Resonance Imaging (MRI), an array of innovative techniques are emerging that incorporate the use of contrast agents, with a particular focus on their application in the diagnosis of cancer. These cutting-edge strategies commonly involve the integration of MRI with a biocompatible targeting entity and Magnetic Nanoparticles (MNPs), a combination that has demonstrated significant efficacy in the detection of cancerous cells. Among these pioneering approaches, one strategy that shows remarkable promise involves the coupling of MRI with a Nano-drone (NH2-PEGylated Hyaluronic Acid-Manganese ferrite). This novel nano-drone is fabricated using a thermal decomposition method, a process known for its precision and reliability. The resultant Nano-drone exhibits sensitivity to T2 weighted or T2 Turbo Spin Echo (TSE) MRI, paving the way for new diagnostic possibilities in the realm of cancer detection. To validate the efficacy of this innovative approach, we designed an experiment that involved the injection of a specific Gastric Cancer cell line, known as MKN-45, into murine gastric tissue. This strategic application allowed us to closely monitor the interaction of the Nano-drone with the cancer cells. In the subsequent stages of the experiment, we utilized T2 TSE magnetic resonance sequences to evaluate the imaging impact of the Nano-drone. This assessment was crucial in determining the targeting proficiency of the Nano-drone, and how effectively it could pinpoint the cancer cells within the gastric tissue. Our findings from this comprehensive study suggest the potential of the Nano-drone as a groundbreaking probe for the visualization of Gastric Cancer. Furthermore, they underscore the significance of TSE validation in unveiling new diagnostic possibilities. The results of our study offer a beacon of hope in the fight against cancer, demonstrating the potential of the Nano-drone to open new avenues in cancer diagnosis and treatment.