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Prevalence of nonalcoholic fatty liver disease in pediatrics and adolescents: a systematic review and meta-analysis

Authors
 Eun Joo Lee  ;  Miyoung Choi  ;  Sang Bong Ahn  ;  Jeong-Ju Yoo  ;  Seong Hee Kang  ;  Yuri Cho  ;  Do Seon Song  ;  Hong Koh  ;  Dae Won Jun  ;  Hye Won Lee 
Citation
 WORLD JOURNAL OF PEDIATRICS, Vol.20(6) : 569-580, 2024-06 
Journal Title
WORLD JOURNAL OF PEDIATRICS
ISSN
 1708-8569 
Issue Date
2024-06
MeSH
Adolescent ; Child ; Global Health ; Humans ; Non-alcoholic Fatty Liver Disease* / epidemiology ; Pediatric Obesity / epidemiology ; Prevalence
Keywords
Meta-analysis ; Nonalcoholic fatty liver disease ; Pediatric ; Prevalence
Abstract
BackgroundAs childhood obesity escalates worldwide, the prevalence of nonalcoholic fatty liver disease (NAFLD) in pediatric and adolescent populations is also increasing. However, systematic studies and meta-analyses evaluating the prevalence of pediatric NAFLD remain limited.MethodsThe MEDLINE, Korean Medical Database (KMBASE), Embase, Global Health, and Cochrane Library databases were searched from January 1997 to April 2023. Search terms included NAFLD or steatosis; nonalcoholic or steatohepatitis; child(ren), adolescent, or teenager; and prevalence, incidence, or epidemiology. A random-effects meta-analysis model was used to estimate the prevalence of pediatric NAFLD.ResultsA total of 2116 publications were found, of which 62 were included in the meta-analysis. Among them, 27 reported the prevalence in the general population and 39 in the obese population. The worldwide pooled prevalence of pediatric NAFLD was 13% [95% confidence interval (CI) 9-18%] in the general population and 47% (95% CI 41%-53%) in the obese population. Among 16 studies in the general population and 18 in the obese population, NAFLD prevalence varied by gender. In the general population, the prevalence of NAFLD was 15% (95% CI 8%-23%) in males and 10% (95% CI 6%-15%) in females. In the obese population, it was 54% (95% CI 46%-61%) in males and 39% (95% CI 30%-49%) in females.ConclusionsThe global prevalence of pediatric NAFLD is rising in both the general and obese populations. Given the increasing rates of childhood obesity, epidemiological studies on the prevalence and incidence of NAFLD are needed.
Full Text
https://link.springer.com/article/10.1007/s12519-024-00814-1
DOI
10.1007/s12519-024-00814-1
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers
Yonsei Authors
Koh, Hong(고홍) ORCID logo https://orcid.org/0000-0002-3660-7483
Lee, Eun Joo(이은주)
Lee, Hye Won(이혜원) ORCID logo https://orcid.org/0000-0002-3552-3560
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200721
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