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Sarcomatoid change in combined hepatocellular carcinoma and cholangiocarcinoma as a poor prognostic factor

Authors
 Suk Won Lee  ;  Milim Kim  ;  Sung Hyun Kim  ;  Dai Hoon Han  ;  Gi Hong Choi  ;  Kyung Sik Kim  ;  Jin Sub Choi  ;  Young Nyun Park 
Citation
 JOURNAL OF GASTROINTESTINAL ONCOLOGY, Vol.15(4) : 1796-1804, 2024-08 
Journal Title
JOURNAL OF GASTROINTESTINAL ONCOLOGY
ISSN
 2078-6891 
Issue Date
2024-08
Keywords
Combined hepatocellular-cholangiocarcinoma (cHCC-CC) ; hepatectomy ; prognosis ; sarcomatoid change ; survival analysis
Abstract
Background: Sarcomatoid change is rarely seen in epithelial malignancy that can be observed in diverse organs. Although a sarcomatoid change in combined hepatocellular-cholangiocarcinoma (cHCC-CC) is assumed to be a poor prognostic factor, this issue has not been studied due to its rare incidence. In this study, we aimed to identify the oncological impact of sarcomatoid change in patients with cHCC-CC and verify that sarcomatoid change is a poor prognostic factor for resected cHCC-CC. Methods: Between January 2006 and December 2020, 102 patients who underwent surgical resection for cHCC-CC were retrospectively reviewed. The hazard ratio (HR) according to sarcomatoid change was calculated using other known prognostic factors for cHCC-CC. In addition, the patients were divided into two groups according to the sarcomatoid change, and their survival was compared. Results: The multivariate analysis demonstrated that sarcomatoid change in cHCC-CC is a poor prognostic factor {disease-free survival (DFS), HR =3.84 [95% confidence interval (CI): 1.63–9.10], P=0.002; overall survival (OS), HR =3.94 (95% CI: 1.67–9.31), P=0.002}. In the survival analysis, the sarcomatoid change group displayed a worse prognosis compared to the non-sarcomatoid change group {DFS: 4.0 [interquartile range (IQR): 1.2–6.8] vs. 23.0 (IQR: 9.3–36.7) months, P=0.001; OS: 19.0 (IQR: 7.2–30.8) vs. 85.0 (IQR: 31.8–138.2) months, P=0.004}. Conclusions: Sarcomatoid change is a poor prognostic factor for resected cHCC-CC.
Files in This Item:
T202405492.pdf Download
DOI
39279943
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Milim(김미림)
Kim, Sung Hyun(김성현) ORCID logo https://orcid.org/0000-0001-7683-9687
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
Choi, Gi Hong(최기홍) ORCID logo https://orcid.org/0000-0002-1593-3773
Choi, Jin Sub(최진섭)
Han, Dai Hoon(한대훈) ORCID logo https://orcid.org/0000-0003-2787-7876
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200541
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