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Microfluidics-based condensation bioaerosol sampler for multipoint airborne virus monitoring

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dc.contributor.author김민구-
dc.date.accessioned2024-10-04T02:03:57Z-
dc.date.available2024-10-04T02:03:57Z-
dc.date.issued2024-11-
dc.identifier.issn0956-5663-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/200384-
dc.description.abstractTo facilitate rapid monitoring of airborne viruses, they must be collected with high efficiency and concentrated in a small volume of a liquid sample. In addition, the development of low-cost miniaturized samplers is essential for multipoint monitoring. Thus, in an attempt to fulfill these requirements, this study developed a microfluidic condensation bioaerosol sampler (MCBS). The developed sampler comprised two parts: a virus growth section and a virus droplet-to-liquid sample conversion section, each of which was fabricated on a chip using microfluidic technology. The condensation nucleus growth technique used in the virus growth section grew nanometer-sized airborne viruses into micro-sized droplets, making it possible to collection of viruses easier and with high efficiency. In addition, the virus droplet-to-liquid sample conversion section controlled the transport of droplets based on electrowetting technology. This enabled the collected airborne viruses to be concentrated in tens of microliters of the liquid sample. To evaluate the performance of both the sections, the virus dropletization, virus collection efficiency, and virus droplet-to-liquid sample conversion efficiency were evaluated through quantitative experiments. H1N1 and HCOV-229E viruses were used to conduct quantitative experiments on MCBS. We could obtain virus liquid samples with at 72.8- and 89.9-times higher concentration through 1:1 evaluation with a commercial sampler. Thus, the developed sampler facilitated efficient collection and concentration of airborne viruses in a compact, cost-effective manner. This is expected to facilitate rapid and accurate multipoint monitoring of viral aerosols.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier Advanced Technology-
dc.relation.isPartOfBIOSENSORS & BIOELECTRONICS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAerosols* / analysis-
dc.subject.MESHAir Microbiology*-
dc.subject.MESHBiosensing Techniques* / instrumentation-
dc.subject.MESHEnvironmental Monitoring / instrumentation-
dc.subject.MESHEnvironmental Monitoring / methods-
dc.subject.MESHEquipment Design*-
dc.subject.MESHHumans-
dc.subject.MESHInfluenza A Virus, H1N1 Subtype / isolation & purification-
dc.subject.MESHLab-On-A-Chip Devices-
dc.subject.MESHMicrofluidic Analytical Techniques / instrumentation-
dc.subject.MESHMicrofluidics / instrumentation-
dc.titleMicrofluidics-based condensation bioaerosol sampler for multipoint airborne virus monitoring-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorSeong-Jae Yoo-
dc.contributor.googleauthorJaeho Oh-
dc.contributor.googleauthorSeung-Jae Hong-
dc.contributor.googleauthorMin-Gu Kim-
dc.contributor.googleauthorJungho Hwang-
dc.contributor.googleauthorYong-Jun Kim-
dc.identifier.doi39137520-
dc.contributor.localIdA06575-
dc.relation.journalcodeJ00330-
dc.identifier.eissn1873-4235-
dc.identifier.pmid10.1016/j.bios.2024.116658-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S095656632400664X-
dc.subject.keywordBio aerosol-
dc.subject.keywordCondensational growth-
dc.subject.keywordElectrowetting-
dc.subject.keywordMicrofluidics-
dc.subject.keywordVirus monitoring-
dc.subject.keywordVirus sampler-
dc.contributor.alternativeNameKim, Min-Gu-
dc.contributor.affiliatedAuthor김민구-
dc.citation.volume264-
dc.citation.startPage116658-
dc.identifier.bibliographicCitationBIOSENSORS & BIOELECTRONICS, Vol.264 : 116658, 2024-11-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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