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Hepatitis C virus infection in patients undergoing surgery in a single tertiary academic center

Authors
 Jae Seung Lee  ;  Hye Won Lee  ;  Mi Na Kim  ;  Beom Kyung Kim  ;  Jun Yong Park  ;  Do Young Kim  ;  Sang Hoon Ahn  ;  Seung Up Kim 
Citation
 JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.39(6) : 1155-1163, 2024-06 
Journal Title
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
ISSN
 0815-9319 
Issue Date
2024-06
MeSH
Adult ; Aged ; Antiviral Agents* / therapeutic use ; Female ; Hepacivirus / genetics ; Hepacivirus / immunology ; Hepatitis C Antibodies / blood ; Hepatitis C* / diagnosis ; Humans ; Liver Cirrhosis / surgery ; Male ; Mass Screening / methods ; Middle Aged ; RNA, Viral / blood ; Retrospective Studies ; Surgical Procedures, Operative / adverse effects ; Tertiary Care Centers*
Keywords
care cascade ; early diagnosis ; hepatitis C virus ; hepatitis C, chronic ; screening
Abstract
Background and aim: Lack of awareness disturbs proper care for hepatitis C virus (HCV) infections in patients undergoing surgery. We investigated the status of HCV screening, confirmation, and treatment in patients who underwent surgery.

Methods: Patients who underwent surgery at a tertiary academic center between 2019 and 2021 were eligible for this retrospective study.

Results: Between 2019 and 2021, 96 894 patients (40 121 males; 41.4%) who underwent surgery under general anesthesia were recruited. The median age of the participants was 55.0 years. Of the 83 920 (86.6%) patients who tested positive for anti-HCV antibodies, 576 (0.7%) showed positive results, with a higher proportion of patients with diabetes mellitus (32.6% vs 18.5%), hypertension (50.5% vs 28.6%), liver cirrhosis (13.2% vs 1.7%), and unfavorable laboratory test results when compared with those with negative results (all P < 0.05). HCV RNA was tested in 215 patients (37.3%), with a positivity rate of 20.5% (n = 44). Of the 44 patients, 42 (95.5%) were referred for antiviral treatment, and 29 (69.0%) were successfully treated with direct-acting antiviral therapy. HCV RNA confirmation rates were higher in the Department of Hepatobiliary and Transplant Surgery (76.6%) than in the other surgical departments (25.0-33.5%) (P < 0.001).

Conclusions: The proportion of patients who were positive for anti-HCV antibodies and failed to receive proper management after surgery was not negligible. Increased awareness of HCV infection among surgeons through appropriate education may be required.
Full Text
https://onlinelibrary.wiley.com/doi/10.1111/jgh.16506
DOI
10.1111/jgh.16506
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Mina(김미나) ORCID logo https://orcid.org/0000-0002-1675-0688
Kim, Beom Kyung(김범경) ORCID logo https://orcid.org/0000-0002-5363-2496
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Lee, Jae Seung(이재승) ORCID logo https://orcid.org/0000-0002-2371-0967
Lee, Hye Won(이혜원) ORCID logo https://orcid.org/0000-0002-3552-3560
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/200185
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