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Optimal Systolic Blood Pressure for the Prevention of All-Cause and Cardiovascular Disease Mortality in Older Adults With Hypertension: Nationwide Population-Based Cohort Study
DC Field | Value | Language |
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dc.contributor.author | 이경희 | - |
dc.date.accessioned | 2024-07-18T05:31:08Z | - |
dc.date.available | 2024-07-18T05:31:08Z | - |
dc.date.issued | 2024-06 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/200117 | - |
dc.description.abstract | BACKGROUND: Target systolic blood pressure (SBP) levels for older adults with hypertension vary across countries, leading to challenges in determining the appropriate SBP level. OBJECTIVE: This study aims to identify the optimal SBP level for minimizing all-cause and cardiovascular disease (CVD) mortality in older Korean adults with hypertension. METHODS: This retrospective cohort study used data from the National Health Insurance Service database. We included older adults aged 65 years or older who were newly diagnosed with hypertension and underwent a National Health Insurance Service health checkup in 2003-2004. We excluded patients who had a history of hypertension or CVD, were not prescribed medication for hypertension, had missing blood pressure or any other covariate values, and had fewer than 2 health checkups during the follow-up period until 2020. We categorized the average SBP levels into 6 categories in 10 mm Hg increments, from <120 mm Hg to ≥160 mm Hg; 130-139 mm Hg was the reference range. Cox proportional hazards models were used to examine the relationship between SBP and all-cause and CVD mortalities, and subgroup analysis was conducted by age group (65-74 years and 75 years or older). RESULTS: A total of 68,901 older adults newly diagnosed with hypertension were included in this study. During the follow-up period, 32,588 (47.3%) participants had all-cause mortality and 4273 (6.2%) had CVD mortality. Compared to older adults with SBP within the range of 130-139 mm Hg, individuals who fell into the other SBP categories, excluding those with SBP 120-129 mm Hg, showed significantly higher all-cause and CVD mortality. Subgroup analysis showed that older adults aged 65-74 years had higher all-cause and CVD mortality rates according to SBP categories than those aged 75 years or older. CONCLUSIONS: The SBP levels within the range of 120-139 mm Hg were associated with the lowest all-cause and CVD mortality rates among older Korean adults with hypertension. It is recommended to reduce SBP to <140 mm Hg, with 120 mm Hg as the minimum value for SBP, for older Korean adults with hypertension. Additionally, stricter SBP management is required for adults aged 65-74 years. ©Jae Jun Lee, Kyung Hee Lee. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org), 11.06.2024. | - |
dc.description.statementOfResponsibility | open | - |
dc.relation.isPartOf | JMIR PUBLIC HEALTH AND SURVEILLANCE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Blood Pressure* / physiology | - |
dc.subject.MESH | Cardiovascular Diseases* / mortality | - |
dc.subject.MESH | Cardiovascular Diseases* / prevention & control | - |
dc.subject.MESH | Cause of Death / trends | - |
dc.subject.MESH | Cohort Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Hypertension* / epidemiology | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Republic of Korea / epidemiology | - |
dc.subject.MESH | Retrospective Studies | - |
dc.title | Optimal Systolic Blood Pressure for the Prevention of All-Cause and Cardiovascular Disease Mortality in Older Adults With Hypertension: Nationwide Population-Based Cohort Study | - |
dc.type | Article | - |
dc.contributor.college | College of Nursing (간호대학) | - |
dc.contributor.department | Dept. of Nursing (간호학과) | - |
dc.contributor.googleauthor | Jae Jun Lee | - |
dc.contributor.googleauthor | Kyung Hee Lee | - |
dc.identifier.doi | 10.2196/52182 | - |
dc.contributor.localId | A02663 | - |
dc.relation.journalcode | J04162 | - |
dc.identifier.pmid | 38861307 | - |
dc.subject.keyword | Korea | - |
dc.subject.keyword | Korean | - |
dc.subject.keyword | aged | - |
dc.subject.keyword | aging | - |
dc.subject.keyword | blood pressure | - |
dc.subject.keyword | cardiovascular | - |
dc.subject.keyword | cardiovascular diseases | - |
dc.subject.keyword | cohort study | - |
dc.subject.keyword | elderly | - |
dc.subject.keyword | geriatric | - |
dc.subject.keyword | health outcome | - |
dc.subject.keyword | hypertension | - |
dc.subject.keyword | insurance | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | older adults | - |
dc.subject.keyword | risk | - |
dc.subject.keyword | systolic | - |
dc.contributor.alternativeName | Lee, Kyung Hee | - |
dc.contributor.affiliatedAuthor | 이경희 | - |
dc.citation.volume | 10 | - |
dc.citation.startPage | e52182 | - |
dc.identifier.bibliographicCitation | JMIR PUBLIC HEALTH AND SURVEILLANCE, Vol.10 : e52182, 2024-06 | - |
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